E2F5 (E2F transcription factor 5)

2003-02-01  

Identity

HGNC
LOCATION
8q21.2
LOCUSID
ALIAS
E2F-5
FUSION GENES

Other Information

Locus ID:

NCBI: 1875
MIM: 600967
HGNC: 3119
Ensembl: ENSG00000133740

Variants:

dbSNP: 1875
ClinVar: 1875
TCGA: ENSG00000133740
COSMIC: E2F5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133740ENST00000256117C9JYE9
ENSG00000133740ENST00000416274Q15329
ENSG00000133740ENST00000418930Q15329
ENSG00000133740ENST00000517476Q15329
ENSG00000133740ENST00000518234H0YBK0
ENSG00000133740ENST00000520225H0YBW8
ENSG00000133740ENST00000521429E5RHD4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
TGF-beta signaling pathwayKEGGko04350
Cell cycleKEGGhsa04110
TGF-beta signaling pathwayKEGGhsa04350
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231

References

Pubmed IDYearTitleCitations
127892592003pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.41
282321822017SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5.38
128609722003Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.31
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
192590952009Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome.22
245291712014Up-regulated MicroRNA-181a induces carcinogenesis in hepatitis B virus-related hepatocellular carcinoma by targeting E2F5.21
201812302010E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer.20
261030032015MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer.19
197386112009Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.17
212743762011A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma.16

Citation

Dessen P

E2F5 (E2F transcription factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40386/e2f5