E2F7 (E2F transcription factor 7)

2007-04-01 Affiliation

Identity

HGNC

E2F7

LOCATION

12q21.2

LOCUSID

144455

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 144455
MIM: 612046
HGNC: 23820
Ensembl: ENSG00000165891

Variants:

dbSNP: 144455
ClinVar: 144455
TCGA: ENSG00000165891
COSMIC: E2F7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165891	ENST00000322886	Q96AV8
ENSG00000165891	ENST00000416496	Q96AV8
ENSG00000165891	ENST00000547316	F8VXV5
ENSG00000165891	ENST00000550669	F8VSE7
ENSG00000165891	ENST00000551058	H0YIF4
ENSG00000165891	ENST00000552907	H0YHW2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Transcription of Cell Cycle Genes	REACTOME	R-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	REACTOME	R-HSA-6804116

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated		PD
PA451581	tamoxifen	Chemical	ClinicalAnnotation	associated		PD	23508821

References

Pubmed ID	Year	Title	Citations
14633988	2003	E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes.	92
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
18202719	2008	DNA-damage response control of E2F7 and E2F8.	63
22802529	2012	The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.	53
15897886	2005	E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.	52
22802528	2012	E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.	51
17200349	2007	Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients.	41
19223542	2009	E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation.	24
23096114	2012	The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.	24
26397135	2015	E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter.	22

Citation

Dessen P

E2F7 (E2F transcription factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47032/e2f7