EAF2 (ELL associated factor 2)

2007-02-01  

Identity

HGNC
EAF2
LOCATION
3q13.33
LOCUSID
55840
ALIAS
BM040,TRAITS,U19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55840
MIM: 607659
HGNC: 23115
Ensembl: ENSG00000145088

Variants:

dbSNP: 55840
ClinVar: 55840
TCGA: ENSG00000145088
COSMIC: EAF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145088ENST00000273668Q96CJ1
ENSG00000145088ENST00000451944B4DWJ3
ENSG00000145088ENST00000490434F8WCI9
ENSG00000145088ENST00000490477F8WF04

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
129076522003Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer.50
160065232005ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.46
198264142010Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53.27
244213872014EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.16
161140572006ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.14
258088532015FOXA1 modulates EAF2 regulation of AR transcriptional activity, cell proliferation, and migration in prostate cancer cells.11
201617472010Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19.9
272592642016EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling.9
277214052017EAF2 regulates DNA repair through Ku70/Ku80 in the prostate.8

Citation

Dessen P

EAF2 (ELL associated factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45970/eaf2