ECI1 (enoyl-CoA delta isomerase 1)

2014-11-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
DCI
FUSION GENES

Other Information

Locus ID:

NCBI: 1632
MIM: 600305
HGNC: 2703
Ensembl: ENSG00000167969

Variants:

dbSNP: 1632
ClinVar: 1632
TCGA: ENSG00000167969
COSMIC: ECI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167969ENST00000301729P42126
ENSG00000167969ENST00000301729A0A384NKJ3
ENSG00000167969ENST00000562238P42126
ENSG00000167969ENST00000566379H3BS70
ENSG00000167969ENST00000570258Q96DC0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Fatty acid degradationKEGGko00071
Fatty acid degradationKEGGhsa00071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Mitochondrial Fatty Acid Beta-OxidationREACTOMER-HSA-77289
mitochondrial fatty acid beta-oxidation of unsaturated fatty acidsREACTOMER-HSA-77288

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219179522011Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis.26
153516452004The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.12

Citation

Dessen P

ECI1 (enoyl-CoA delta isomerase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62716/eci1