EDN2 (endothelin 2)

2007-02-01  

Identity

HGNC
EDN2
LOCATION
1p34.2
LOCUSID
1907
ALIAS
ET-2,ET2,PPET2

Other Information

Locus ID:

NCBI: 1907
MIM: 131241
HGNC: 3177
Ensembl: ENSG00000127129

Variants:

dbSNP: 1907
ClinVar: 1907
TCGA: ENSG00000127129
COSMIC: EDN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127129ENST00000372587P20800

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
122073232002Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.35
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26
125169602002Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells.22
195274882009Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.21
240438152013Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.21
193363702009Determination of genetic predisposition to patent ductus arteriosus in preterm infants.17
228656322013Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.16

Citation

Dessen P

EDN2 (endothelin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46014/edn2