EDNRA (endothelin receptor type A)

2007-02-01  

Identity

HGNC
LOCATION
4q31.22
LOCUSID
ALIAS
ET-A,ETA,ETA-R,ETAR,ETRA,MFDA,hET-AR

Other Information

Locus ID:

NCBI: 1909
MIM: 131243
HGNC: 3179
Ensembl: ENSG00000151617

Variants:

dbSNP: 1909
ClinVar: 1909
TCGA: ENSG00000151617
COSMIC: EDNRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151617ENST00000324300P25101
ENSG00000151617ENST00000358556P25101
ENSG00000151617ENST00000506066P25101
ENSG00000151617ENST00000510697P25101
ENSG00000151617ENST00000511804P25101
ENSG00000151617ENST00000648866P25101
ENSG00000151617ENST00000651419P25101

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150478662004Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.97
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
212204762011Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells.65
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
222861732012Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.39
221063122011Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk.35
252251832014Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.35
278994872017Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility.35
150731162004Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer.33
145196352003Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up.32

Citation

Dessen P

EDNRA (endothelin receptor type A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45792/ednra