EEF2 (eukaryotic translation elongation factor 2)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
EEF-2,EF-2,EF2,SCA26
FUSION GENES

Other Information

Locus ID:

NCBI: 1938
MIM: 130610
HGNC: 3214
Ensembl: ENSG00000167658

Variants:

dbSNP: 1938
ClinVar: 1938
TCGA: ENSG00000167658
COSMIC: EEF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167658ENST00000309311P13639
ENSG00000167658ENST00000309311A0A384N6H1
ENSG00000167658ENST00000600794M0R0I6

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Synthesis of diphthamide-EEF2REACTOMER-HSA-5358493
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of diphtheria toxinREACTOMER-HSA-5336415
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Neutrophil degranulationREACTOMER-HSA-6798695
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160982022005Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain.97
166484882006Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
2202093720111-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.30
231846622013Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.27
193603312009Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.25
201816272010Identification of melanoma antigens using a Serological Proteome Approach (SERPA).21
297481842018Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion.19
230015652012A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult.18
190368252009Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type.17

Citation

Dessen P

EEF2 (eukaryotic translation elongation factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40410/eef2