Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EFNA4 (ephrin A4)

Identity

Alias_namesEPLG4
ephrin-A4
Alias_symbol (synonym)LERK4
Other aliasEFL4
HGNC (Hugo) EFNA4
LocusID (NCBI) 1945
Atlas_Id 51304
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 155063737 and ends at 155069553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EFNA4 (1q22) / C20orf96 (20p13)EFNA4 (1q22) / FLAD1 (1q21.3)EFNA4 (1q22) / RUSC1 (1q22)
EFNA4 1q22 / C20orf96 20p13EFNA4 1q22 / FLAD1 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q21;q22) EFNA4/FLAD1

External links

Nomenclature
HGNC (Hugo)EFNA4   3224
Cards
Entrez_Gene (NCBI)EFNA4  1945  ephrin A4
AliasesEFL4; EPLG4; LERK4
GeneCards (Weizmann)EFNA4
Ensembl hg19 (Hinxton)ENSG00000243364 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243364 [Gene_View]  ENSG00000243364 [Sequence]  chr1:155063737-155069553 [Contig_View]  EFNA4 [Vega]
ICGC DataPortalENSG00000243364
TCGA cBioPortalEFNA4
AceView (NCBI)EFNA4
Genatlas (Paris)EFNA4
WikiGenes1945
SOURCE (Princeton)EFNA4
Genetics Home Reference (NIH)EFNA4
Genomic and cartography
GoldenPath hg38 (UCSC)EFNA4  -     chr1:155063737-155069553 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EFNA4  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathEFNA4 - 1q21.3 [CytoView hg19]  EFNA4 - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000243364
Mapping of homologs : NCBIEFNA4 [Mapview hg19]  EFNA4 [Mapview hg38]
OMIM601380   
Gene and transcription
Genbank (Entrez)AI459151 AI625552 AJ006352 AJ006353 BC042610
RefSeq transcript (Entrez)NM_005227 NM_182689 NM_182690
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EFNA4
Cluster EST : UnigeneHs.639422 [ NCBI ]
CGAP (NCI)Hs.639422
Alternative Splicing GalleryENSG00000243364
Gene ExpressionEFNA4 [ NCBI-GEO ]   EFNA4 [ EBI - ARRAY_EXPRESS ]   EFNA4 [ SEEK ]   EFNA4 [ MEM ]
Gene Expression Viewer (FireBrowse)EFNA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1945
GTEX Portal (Tissue expression)EFNA4
Human Protein AtlasENSG00000243364-EFNA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52798   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52798  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52798
Splice isoforms : SwissVarP52798
PhosPhoSitePlusP52798
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin-A_Ecto    Ephrin_CS    Ephrin_RBD   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Domain structure : Prodom (Prabi Lyon)Ephrin (PD002533)   
Conserved Domain (NCBI)EFNA4
DMDM Disease mutations1945
Blocks (Seattle)EFNA4
SuperfamilyP52798
Human Protein Atlas [tissue]ENSG00000243364-EFNA4 [tissue]
Peptide AtlasP52798
HPRD03224
IPIIPI00005125   IPI00942714   IPI00746790   IPI00377018   
Protein Interaction databases
DIP (DOE-UCLA)P52798
IntAct (EBI)P52798
FunCoupENSG00000243364
BioGRIDEFNA4
STRING (EMBL)EFNA4
ZODIACEFNA4
Ontologies - Pathways
QuickGOP52798
Ontology : AmiGOtransmembrane-ephrin receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  osteoclast differentiation  anchored component of membrane  intrinsic component of plasma membrane  bone remodeling  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Ontology : EGO-EBItransmembrane-ephrin receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  osteoclast differentiation  anchored component of membrane  intrinsic component of plasma membrane  bone remodeling  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Axon guidance   
NDEx NetworkEFNA4
Atlas of Cancer Signalling NetworkEFNA4
Wikipedia pathwaysEFNA4
Orthology - Evolution
OrthoDB1945
GeneTree (enSembl)ENSG00000243364
Phylogenetic Trees/Animal Genes : TreeFamEFNA4
HOGENOMP52798
Homologs : HomoloGeneEFNA4
Homology/Alignments : Family Browser (UCSC)EFNA4
Gene fusions - Rearrangements
Fusion : MitelmanEFNA4/FLAD1 [1q22/1q21.3]  
Fusion PortalEFNA4 1q22 C20orf96 20p13 BRCA
Fusion PortalEFNA4 1q22 FLAD1 1q21.3 BRCA LUSC
Fusion : QuiverEFNA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEFNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EFNA4
dbVarEFNA4
ClinVarEFNA4
1000_GenomesEFNA4 
Exome Variant ServerEFNA4
ExAC (Exome Aggregation Consortium)ENSG00000243364
GNOMAD BrowserENSG00000243364
Varsome BrowserEFNA4
Genetic variants : HAPMAP1945
Genomic Variants (DGV)EFNA4 [DGVbeta]
DECIPHEREFNA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEFNA4 
Mutations
ICGC Data PortalEFNA4 
TCGA Data PortalEFNA4 
Broad Tumor PortalEFNA4
OASIS PortalEFNA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEFNA4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEFNA4
Mutations and Diseases : HGMDEFNA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EFNA4
DgiDB (Drug Gene Interaction Database)EFNA4
DoCM (Curated mutations)EFNA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EFNA4 (select a term)
intoGenEFNA4
Cancer3DEFNA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601380   
Orphanet
DisGeNETEFNA4
MedgenEFNA4
Genetic Testing Registry EFNA4
NextProtP52798 [Medical]
TSGene1945
GENETestsEFNA4
Target ValidationEFNA4
Huge Navigator EFNA4 [HugePedia]
snp3D : Map Gene to Disease1945
BioCentury BCIQEFNA4
ClinGenEFNA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1945
Chemical/Pharm GKB GenePA27659
Clinical trialEFNA4
Miscellaneous
canSAR (ICR)EFNA4 (select the gene name)
DataMed IndexEFNA4
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEFNA4
EVEXEFNA4
GoPubMedEFNA4
iHOPEFNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:41:32 CET 2019
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