EGR2 (early growth response 2)

2003-02-01  

Identity

HGNC
LOCATION
10q21.3
LOCUSID
ALIAS
AT591,CHN1,CMT1D,CMT4E,KROX20

Other Information

Locus ID:

NCBI: 1959
MIM: 129010
HGNC: 3239
Ensembl: ENSG00000122877

Variants:

dbSNP: 1959
ClinVar: 1959
TCGA: ENSG00000122877
COSMIC: EGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122877ENST00000242480P11161
ENSG00000122877ENST00000411732P11161
ENSG00000122877ENST00000439032P11161
ENSG00000122877ENST00000637191A0A1B0GUL0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
200677632010MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2.89
223275142012Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.58
210575082010Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination.46
262145892015Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.40
118353752002Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation.33
126870192003EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK.33
205061192010EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.32
215144232011The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.30
281155752017The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.30
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29

Citation

Dessen P

EGR2 (early growth response 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40419/egr2