EIF2A (eukaryotic translation initiation factor 2A)

2011-02-01  

Identity

HGNC
EIF2A
LOCATION
3q25.1
LOCUSID
83939
ALIAS
CDA02,EIF-2A,MST089,MSTP004,MSTP089
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83939
MIM: 609234
HGNC: 3254
Ensembl: ENSG00000144895

Variants:

dbSNP: 83939
ClinVar: 83939
TCGA: ENSG00000144895
COSMIC: EIF2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144895ENST00000273435F8WAE5
ENSG00000144895ENST00000406576Q9BY44
ENSG00000144895ENST00000460851Q9BY44
ENSG00000144895ENST00000462221H7C5Q4
ENSG00000144895ENST00000465535H7C5R5
ENSG00000144895ENST00000477551H7C5Q3
ENSG00000144895ENST00000482093C9IZE1
ENSG00000144895ENST00000487799Q9BY44
ENSG00000144895ENST00000490505F8WAT3
ENSG00000144895ENST00000494558F8WF18

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
310235832019ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.18
159615452005Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
282403152017Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.9
294862832018Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma.7
299915282018PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance.7
292070362018Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts.6
292339682017HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.6
157812412005Mechanical force activates eIF-2alpha phospho-kinases in fibroblast.4

Citation

Dessen P

EIF2A (eukaryotic translation initiation factor 2A)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52079/eif2a