EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

2006-10-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
GCN2,PVOD2
FUSION GENES

Other Information

Locus ID:

NCBI: 440275
MIM: 609280
HGNC: 19687
Ensembl: ENSG00000128829

Variants:

dbSNP: 440275
ClinVar: 440275
TCGA: ENSG00000128829
COSMIC: EIF2AK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128829ENST00000263791Q9P2K8
ENSG00000128829ENST00000558823H0YNY9
ENSG00000128829ENST00000559624Q9P2K8
ENSG00000128829ENST00000560648H0YND8
ENSG00000128829ENST00000560855H0YME5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD24751813
PA449841haloperidolChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24751813, 27023437
PA450688olanzapineChemicalClinicalAnnotationassociatedPD24751813
PA451201quetiapineChemicalClinicalAnnotationassociatedPD24751813
PA451257risperidoneChemicalClinicalAnnotationassociatedPD24751813
PA451974ziprasidoneChemicalClinicalAnnotationassociatedPD24751813

References

Pubmed IDYearTitleCitations
204732722010The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.205
232162492013Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR.78
182870932008MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.33
257594782015Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.26
212035632010Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.25
224355352012AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells.25
239085982013Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway.24
195869042009The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.19
300614202018Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.18
201680912010Autophagy impairment stimulates PS1 expression and gamma-secretase activity.16

Citation

Dessen P

EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43241/eif2ak4