EIF3H (eukaryotic translation initiation factor 3 subunit H)

2003-02-01  

Identity

HGNC
LOCATION
8q23.3
LOCUSID
ALIAS
EIF3S3,eIF3-gamma,eIF3-p40
FUSION GENES

Other Information

Locus ID:

NCBI: 8667
MIM: 603912
HGNC: 3273
Ensembl: ENSG00000147677

Variants:

dbSNP: 8667
ClinVar: 8667
TCGA: ENSG00000147677
COSMIC: EIF3H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147677ENST00000276682B3KS98
ENSG00000147677ENST00000518949E5RJT0
ENSG00000147677ENST00000518995E5RGU4
ENSG00000147677ENST00000519046E5RHC7
ENSG00000147677ENST00000520813E5RFW7
ENSG00000147677ENST00000521861O15372
ENSG00000147677ENST00000521861Q6IB98
ENSG00000147677ENST00000522453E5RFH0
ENSG00000147677ENST00000522800E5RH59
ENSG00000147677ENST00000611080A0A087WZK9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
302324532018mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.62
208623262010Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H.41
206594712010Genetic heterogeneity in colorectal cancer associations between African and European americans.40
117333592001Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer.32
145788632003PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas.30
185445312008An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3.28
192045742009MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.23
192045742009MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.23
149972052004Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.19
204370582010The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.15

Citation

Dessen P

EIF3H (eukaryotic translation initiation factor 3 subunit H)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40427/eif3h