EIF3K (eukaryotic translation initiation factor 3 subunit K)

2012-11-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
ARG134,EIF3-p28,EIF3S12,HSPC029,M9,MSTP001,PLAC-24,PLAC24,PRO1474,PTD001
FUSION GENES

Other Information

Locus ID:

NCBI: 27335
MIM: 609596
HGNC: 24656
Ensembl: ENSG00000178982

Variants:

dbSNP: 27335
ClinVar: 27335
TCGA: ENSG00000178982
COSMIC: EIF3K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178982ENST00000248342Q9UBQ5
ENSG00000178982ENST00000538434B4DQ48
ENSG00000178982ENST00000545173Q9UBQ5
ENSG00000178982ENST00000588934K7ES31
ENSG00000178982ENST00000591409K7EQM4
ENSG00000178982ENST00000592558K7ERF1
ENSG00000178982ENST00000593149K7EK53
ENSG00000178982ENST00000614624A0A087WVB9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151809862004Crystal structure of human eIF3k, the first structure of eIF3 subunits.24
185775802008eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.13
120066652002PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.8
153279892004Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.7
240363612013The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies.4
318635852020Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.1

Citation

Dessen P

EIF3K (eukaryotic translation initiation factor 3 subunit K)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52996/eif3k