EIF4A1 (eukaryotic translation initiation factor 4A1)

2007-04-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
DDX2A,EIF-4A,EIF4A,eIF-4A-I,eIF4A-I
FUSION GENES

Other Information

Locus ID:

NCBI: 1973
MIM: 602641
HGNC: 3282
Ensembl: ENSG00000161960

Variants:

dbSNP: 1973
ClinVar: 1973
TCGA: ENSG00000161960
COSMIC: EIF4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161960ENST00000293831P60842
ENSG00000161960ENST00000577269P60842
ENSG00000161960ENST00000577929J3KS93
ENSG00000161960ENST00000578476J3QRP5
ENSG00000161960ENST00000578495J3QS69
ENSG00000161960ENST00000578754J3KTN0
ENSG00000161960ENST00000579139J3KRC2
ENSG00000161960ENST00000580461J3QRP5
ENSG00000161960ENST00000580888J3KSP3
ENSG00000161960ENST00000581384J3QR64
ENSG00000161960ENST00000581544J3QQP0
ENSG00000161960ENST00000581770J3KT04
ENSG00000161960ENST00000582050J3QL52
ENSG00000161960ENST00000582169J3QKZ9
ENSG00000161960ENST00000582746J3KT12
ENSG00000161960ENST00000583389J3KSZ0
ENSG00000161960ENST00000583802J3QLN6
ENSG00000161960ENST00000584784J3QL43
ENSG00000161960ENST00000584860J3KTB5
ENSG00000161960ENST00000585024J3KS25

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250793192014RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.178
214277652011mRNA helicases: the tacticians of translational control.146
192035802009Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.105
150827832004A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.81
182966392008PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.53
256113782015The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.47
180341602007Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.44
218403182011Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.40
220763802011A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.40
225893332012A cellular response linking eIF4AI activity to eIF4AII transcription.40

Citation

Dessen P

EIF4A1 (eukaryotic translation initiation factor 4A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46639/eif4a1