EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)

2010-08-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
4EBP2,PHASII
FUSION GENES

Other Information

Locus ID:

NCBI: 1979
MIM: 602224
HGNC: 3289
Ensembl: ENSG00000148730

Variants:

dbSNP: 1979
ClinVar: 1979
TCGA: ENSG00000148730
COSMIC: EIF4EBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148730ENST00000373218Q13542
ENSG00000148730ENST00000373218A0A024QZM3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
242066642013mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.238
255339572015Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.140
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
1184721620024E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
265227192016Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA.13
192444802009The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
187893252008Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E.9

Citation

Dessen P

EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51579/eif4ebp2