Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EIF5A2 (eukaryotic translation initiation factor 5A2)

Identity

Alias (NCBI)EIF-5A2
eIF5AII
HGNC (Hugo) EIF5A2
LocusID (NCBI) 56648
Atlas_Id 40435
Location 3q26.2  [Link to chromosome band 3q26]
Location_base_pair Starts at 170888418 and ends at 170908637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF5A2 (3q26.2) / RAD23B (9q31.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PHC3/EIF5A2 (3q26)

External links

Nomenclature
HGNC (Hugo)EIF5A2   3301
Cards
Entrez_Gene (NCBI)EIF5A2  56648  eukaryotic translation initiation factor 5A2
AliasesEIF-5A2; eIF5AII
GeneCards (Weizmann)EIF5A2
Ensembl hg19 (Hinxton)ENSG00000163577 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163577 [Gene_View]  ENSG00000163577 [Sequence]  chr3:170888418-170908637 [Contig_View]  EIF5A2 [Vega]
ICGC DataPortalENSG00000163577
TCGA cBioPortalEIF5A2
AceView (NCBI)EIF5A2
Genatlas (Paris)EIF5A2
WikiGenes56648
SOURCE (Princeton)EIF5A2
Genetics Home Reference (NIH)EIF5A2
Genomic and cartography
GoldenPath hg38 (UCSC)EIF5A2  -     chr3:170888418-170908637 -  3q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF5A2  -     3q26.2   [Description]    (hg19-Feb_2009)
GoldenPathEIF5A2 - 3q26.2 [CytoView hg19]  EIF5A2 - 3q26.2 [CytoView hg38]
ImmunoBaseENSG00000163577
genome Data Viewer NCBIEIF5A2 [Mapview hg19]  
OMIM605782   
Gene and transcription
Genbank (Entrez)AK311962 AY205258 AY205259 AY205260 AY205261
RefSeq transcript (Entrez)NM_020390
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF5A2
Alternative Splicing GalleryENSG00000163577
Gene ExpressionEIF5A2 [ NCBI-GEO ]   EIF5A2 [ EBI - ARRAY_EXPRESS ]   EIF5A2 [ SEEK ]   EIF5A2 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF5A2 [ Firebrowse - Broad ]
GenevisibleExpression of EIF5A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56648
GTEX Portal (Tissue expression)EIF5A2
Human Protein AtlasENSG00000163577-EIF5A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZV4
Splice isoforms : SwissVarQ9GZV4
PhosPhoSitePlusQ9GZV4
Domaine pattern : Prosite (Expaxy)IF5A_HYPUSINE (PS00302)   
Domains : Interpro (EBI)IF5A-like    NA-bd_OB-fold    Rib_L2_dom2    Trans_elong_IF5A_hypusine_site    Transl_elong_IF5A_C    Translation_prot_SH3-like_sf   
Domain families : Pfam (Sanger)eIF-5a (PF01287)   
Domain families : Pfam (NCBI)pfam01287   
Domain families : Smart (EMBL)eIF-5a (SM01376)  
Conserved Domain (NCBI)EIF5A2
DMDM Disease mutations56648
Blocks (Seattle)EIF5A2
SuperfamilyQ9GZV4
Human Protein Atlas [tissue]ENSG00000163577-EIF5A2 [tissue]
Peptide AtlasQ9GZV4
HPRD10426
IPIIPI00006935   IPI00945644   IPI00946642   IPI00946502   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZV4
IntAct (EBI)Q9GZV4
FunCoupENSG00000163577
BioGRIDEIF5A2
STRING (EMBL)EIF5A2
ZODIACEIF5A2
Ontologies - Pathways
QuickGOQ9GZV4
Ontology : AmiGOtranslation elongation factor activity  protein binding  nuclear pore  endoplasmic reticulum membrane  cytosol  translational elongation  spermatogenesis  positive regulation of cell proliferation  polyamine homeostasis  protein transport  ribosome binding  intracellular membrane-bounded organelle  positive regulation of translational elongation  positive regulation of translational termination  mRNA transport  
Ontology : EGO-EBItranslation elongation factor activity  protein binding  nuclear pore  endoplasmic reticulum membrane  cytosol  translational elongation  spermatogenesis  positive regulation of cell proliferation  polyamine homeostasis  protein transport  ribosome binding  intracellular membrane-bounded organelle  positive regulation of translational elongation  positive regulation of translational termination  mRNA transport  
NDEx NetworkEIF5A2
Atlas of Cancer Signalling NetworkEIF5A2
Wikipedia pathwaysEIF5A2
Orthology - Evolution
OrthoDB56648
GeneTree (enSembl)ENSG00000163577
Phylogenetic Trees/Animal Genes : TreeFamEIF5A2
HOGENOMQ9GZV4
Homologs : HomoloGeneEIF5A2
Homology/Alignments : Family Browser (UCSC)EIF5A2
Gene fusions - Rearrangements
Fusion : QuiverEIF5A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF5A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF5A2
dbVarEIF5A2
ClinVarEIF5A2
1000_GenomesEIF5A2 
Exome Variant ServerEIF5A2
GNOMAD BrowserENSG00000163577
Varsome BrowserEIF5A2
Genetic variants : HAPMAP56648
Genomic Variants (DGV)EIF5A2 [DGVbeta]
DECIPHEREIF5A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF5A2 
Mutations
ICGC Data PortalEIF5A2 
TCGA Data PortalEIF5A2 
Broad Tumor PortalEIF5A2
OASIS PortalEIF5A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF5A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF5A2
Mutations and Diseases : HGMDEIF5A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF5A2
DgiDB (Drug Gene Interaction Database)EIF5A2
DoCM (Curated mutations)EIF5A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF5A2 (select a term)
intoGenEIF5A2
Cancer3DEIF5A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605782   
Orphanet
DisGeNETEIF5A2
MedgenEIF5A2
Genetic Testing Registry EIF5A2
NextProtQ9GZV4 [Medical]
TSGene56648
GENETestsEIF5A2
Target ValidationEIF5A2
Huge Navigator EIF5A2 [HugePedia]
snp3D : Map Gene to Disease56648
BioCentury BCIQEIF5A2
ClinGenEIF5A2
Clinical trials, drugs, therapy
Protein Interactions : CTD56648
Pharm GKB GenePA27727
Clinical trialEIF5A2
Miscellaneous
canSAR (ICR)EIF5A2 (select the gene name)
HarmonizomeEIF5A2
DataMed IndexEIF5A2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF5A2
EVEXEIF5A2
GoPubMedEIF5A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jul 16 15:11:54 CEST 2020
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