Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EIF5B (eukaryotic translation initiation factor 5B)

Identity

Alias_symbol (synonym)IF2
KIAA0741
DKFZp434I036
FLJ10524
Other alias
HGNC (Hugo) EIF5B
LocusID (NCBI) 9669
Atlas_Id 57365
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 99337371 and ends at 99400265 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF3 (2q11.2) / EIF5B (2q11.2)ATP6V0E1 (5q35.1) / EIF5B (2q11.2)DEK (6p22.3) / EIF5B (2q11.2)
EIF3D (22q12.3) / EIF5B (2q11.2)EIF5B (2q11.2) / CCDC113 (16q21)EIF5B (2q11.2) / EIF5B (2q11.2)
EIF5B (2q11.2) / GCN1 (12q24.23)EIF5B (2q11.2) / TXNDC9 (2q11.2)NCL (2q37.1) / EIF5B (2q11.2)
OLFML2A (9q33.3) / EIF5B (2q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EIF5B   30793
Cards
Entrez_Gene (NCBI)EIF5B  9669  eukaryotic translation initiation factor 5B
AliasesIF2
GeneCards (Weizmann)EIF5B
Ensembl hg19 (Hinxton)ENSG00000158417 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158417 [Gene_View]  ENSG00000158417 [Sequence]  chr2:99337371-99400265 [Contig_View]  EIF5B [Vega]
ICGC DataPortalENSG00000158417
TCGA cBioPortalEIF5B
AceView (NCBI)EIF5B
Genatlas (Paris)EIF5B
WikiGenes9669
SOURCE (Princeton)EIF5B
Genetics Home Reference (NIH)EIF5B
Genomic and cartography
GoldenPath hg38 (UCSC)EIF5B  -     chr2:99337371-99400265 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF5B  -     2q11.2   [Description]    (hg19-Feb_2009)
GoldenPathEIF5B - 2q11.2 [CytoView hg19]  EIF5B - 2q11.2 [CytoView hg38]
ImmunoBaseENSG00000158417
Mapping of homologs : NCBIEIF5B [Mapview hg19]  EIF5B [Mapview hg38]
OMIM606086   
Gene and transcription
Genbank (Entrez)AB018284 AF078035 AJ006412 AJ006776 AK001386
RefSeq transcript (Entrez)NM_015904
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF5B
Cluster EST : UnigeneHs.158688 [ NCBI ]
CGAP (NCI)Hs.158688
Alternative Splicing GalleryENSG00000158417
Gene ExpressionEIF5B [ NCBI-GEO ]   EIF5B [ EBI - ARRAY_EXPRESS ]   EIF5B [ SEEK ]   EIF5B [ MEM ]
Gene Expression Viewer (FireBrowse)EIF5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9669
GTEX Portal (Tissue expression)EIF5B
Human Protein AtlasENSG00000158417-EIF5B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60841   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60841  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60841
Splice isoforms : SwissVarO60841
PhosPhoSitePlusO60841
Domaine pattern : Prosite (Expaxy)G_TR_2 (PS51722)   
Domains : Interpro (EBI)EFTu-like_2    P-loop_NTPase    Small_GTP-bd_dom    TF_GTP-bd_dom    TIF_IF2    TIF_IF2_dom3    TIF_IF2_dom3_sf    Transl_B-barrel_sf   
Domain families : Pfam (Sanger)GTP_EFTU (PF00009)    GTP_EFTU_D2 (PF03144)    IF-2 (PF11987)   
Domain families : Pfam (NCBI)pfam00009    pfam03144    pfam11987   
Conserved Domain (NCBI)EIF5B
DMDM Disease mutations9669
Blocks (Seattle)EIF5B
SuperfamilyO60841
Human Protein Atlas [tissue]ENSG00000158417-EIF5B [tissue]
Peptide AtlasO60841
IPIIPI00299254   
Protein Interaction databases
DIP (DOE-UCLA)O60841
IntAct (EBI)O60841
FunCoupENSG00000158417
BioGRIDEIF5B
STRING (EMBL)EIF5B
ZODIACEIF5B
Ontologies - Pathways
QuickGOO60841
Ontology : AmiGORNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  translational initiation  regulation of translational initiation  regulation of translational initiation  metal ion binding  
Ontology : EGO-EBIRNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  translational initiation  regulation of translational initiation  regulation of translational initiation  metal ion binding  
Pathways : KEGGRNA transport   
NDEx NetworkEIF5B
Atlas of Cancer Signalling NetworkEIF5B
Wikipedia pathwaysEIF5B
Orthology - Evolution
OrthoDB9669
GeneTree (enSembl)ENSG00000158417
Phylogenetic Trees/Animal Genes : TreeFamEIF5B
HOGENOMO60841
Homologs : HomoloGeneEIF5B
Homology/Alignments : Family Browser (UCSC)EIF5B
Gene fusions - Rearrangements
Fusion : QuiverEIF5B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF5B
dbVarEIF5B
ClinVarEIF5B
1000_GenomesEIF5B 
Exome Variant ServerEIF5B
ExAC (Exome Aggregation Consortium)ENSG00000158417
GNOMAD BrowserENSG00000158417
Varsome BrowserEIF5B
Genetic variants : HAPMAP9669
Genomic Variants (DGV)EIF5B [DGVbeta]
DECIPHEREIF5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF5B 
Mutations
ICGC Data PortalEIF5B 
TCGA Data PortalEIF5B 
Broad Tumor PortalEIF5B
OASIS PortalEIF5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF5B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF5B
Mutations and Diseases : HGMDEIF5B
BioMutasearch EIF5B
DgiDB (Drug Gene Interaction Database)EIF5B
DoCM (Curated mutations)EIF5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF5B (select a term)
intoGenEIF5B
Cancer3DEIF5B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606086   
Orphanet
DisGeNETEIF5B
MedgenEIF5B
Genetic Testing Registry EIF5B
NextProtO60841 [Medical]
TSGene9669
GENETestsEIF5B
Target ValidationEIF5B
Huge Navigator EIF5B [HugePedia]
snp3D : Map Gene to Disease9669
BioCentury BCIQEIF5B
ClinGenEIF5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9669
Chemical/Pharm GKB GenePA134864457
Clinical trialEIF5B
Miscellaneous
canSAR (ICR)EIF5B (select the gene name)
DataMed IndexEIF5B
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF5B
EVEXEIF5B
GoPubMedEIF5B
iHOPEIF5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:41:46 CET 2019
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