EIF5B (eukaryotic translation initiation factor 5B)

2018-02-01  

Identity

HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
IF2
FUSION GENES

Other Information

Locus ID:

NCBI: 9669
MIM: 606086
HGNC: 30793
Ensembl: ENSG00000158417

Variants:

dbSNP: 9669
ClinVar: 9669
TCGA: ENSG00000158417
COSMIC: EIF5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158417ENST00000289371O60841
ENSG00000158417ENST00000617677A0A087WUT6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185722162008Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases.37
125691732003Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.30
175687752007Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing.30
216974712011Poliovirus switches to an eIF2-independent mode of translation during infection.26
252615522014Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.16
273257462016eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling.11
292984192018Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.7
276946892016eIF5B increases ASAP1 expression to promote HCC proliferation and invasion.5
171610262007Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene.4
302115442018Human eIF5 and eIF1A Compete for Binding to eIF5B.4

Citation

Dessen P

EIF5B (eukaryotic translation initiation factor 5B)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57365/eif5b