Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ELAVL4 (ELAV like RNA binding protein 4)

Identity

Alias_namesHUD
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4
ELAV like neuron-specific RNA binding protein 4
Alias_symbol (synonym)PNEM
Other alias
HGNC (Hugo) ELAVL4
LocusID (NCBI) 1996
Atlas_Id 40438
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 50108920 and ends at 50203785 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGBL4 (1p33) / ELAVL4 (1p33)ELAVL4 (1p33) / FAF1 (1p32.3)GLYR1 (16p13.3) / ELAVL4 (1p33)
ZCCHC11 (1p32.3) / ELAVL4 (1p33)ZCCHC11 1p32.3 / ELAVL4 1p33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p32;p33) ZCCHC11/ELAVL4

External links

Nomenclature
HGNC (Hugo)ELAVL4   3315
Cards
Entrez_Gene (NCBI)ELAVL4  1996  ELAV like RNA binding protein 4
AliasesHUD; PNEM
GeneCards (Weizmann)ELAVL4
Ensembl hg19 (Hinxton)ENSG00000162374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162374 [Gene_View]  ENSG00000162374 [Sequence]  chr1:50108920-50203785 [Contig_View]  ELAVL4 [Vega]
ICGC DataPortalENSG00000162374
TCGA cBioPortalELAVL4
AceView (NCBI)ELAVL4
Genatlas (Paris)ELAVL4
WikiGenes1996
SOURCE (Princeton)ELAVL4
Genetics Home Reference (NIH)ELAVL4
Genomic and cartography
GoldenPath hg38 (UCSC)ELAVL4  -     chr1:50108920-50203785 +  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELAVL4  -     1p33   [Description]    (hg19-Feb_2009)
GoldenPathELAVL4 - 1p33 [CytoView hg19]  ELAVL4 - 1p33 [CytoView hg38]
ImmunoBaseENSG00000162374
Mapping of homologs : NCBIELAVL4 [Mapview hg19]  ELAVL4 [Mapview hg38]
OMIM168360   
Gene and transcription
Genbank (Entrez)AK297338 AK298817 AK298902 AK309653 AW950943
RefSeq transcript (Entrez)NM_001144774 NM_001144775 NM_001144776 NM_001144777 NM_001294348 NM_001324208 NM_001324209 NM_001324212 NM_001324213 NM_001324214 NM_001324215 NM_001324216 NM_001324217 NM_021952
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ELAVL4
Cluster EST : UnigeneHs.213050 [ NCBI ]
CGAP (NCI)Hs.213050
Alternative Splicing GalleryENSG00000162374
Gene ExpressionELAVL4 [ NCBI-GEO ]   ELAVL4 [ EBI - ARRAY_EXPRESS ]   ELAVL4 [ SEEK ]   ELAVL4 [ MEM ]
Gene Expression Viewer (FireBrowse)ELAVL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1996
GTEX Portal (Tissue expression)ELAVL4
Human Protein AtlasENSG00000162374-ELAVL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26378   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26378
Splice isoforms : SwissVarP26378
PhosPhoSitePlusP26378
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)ELAD_HU_SF    ELAV/Hu_RRM1    HuD_RRM3    Hud_Sxl_RNA    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)ELAVL4
DMDM Disease mutations1996
Blocks (Seattle)ELAVL4
PDB (RSDB)1FXL    1G2E   
PDB Europe1FXL    1G2E   
PDB (PDBSum)1FXL    1G2E   
PDB (IMB)1FXL    1G2E   
Structural Biology KnowledgeBase1FXL    1G2E   
SCOP (Structural Classification of Proteins)1FXL    1G2E   
CATH (Classification of proteins structures)1FXL    1G2E   
SuperfamilyP26378
Human Protein Atlas [tissue]ENSG00000162374-ELAVL4 [tissue]
Peptide AtlasP26378
HPRD01343
IPIIPI00479625   IPI00395507   IPI00607677   IPI00644588   IPI00470469   IPI00978372   IPI00513758   IPI00643012   
Protein Interaction databases
DIP (DOE-UCLA)P26378
IntAct (EBI)P26378
FunCoupENSG00000162374
BioGRIDELAVL4
STRING (EMBL)ELAVL4
ZODIACELAVL4
Ontologies - Pathways
QuickGOP26378
Ontology : AmiGOmRNA 3'-UTR binding  mRNA processing  mRNA 3'-UTR AU-rich region binding  
Ontology : EGO-EBImRNA 3'-UTR binding  mRNA processing  mRNA 3'-UTR AU-rich region binding  
NDEx NetworkELAVL4
Atlas of Cancer Signalling NetworkELAVL4
Wikipedia pathwaysELAVL4
Orthology - Evolution
OrthoDB1996
GeneTree (enSembl)ENSG00000162374
Phylogenetic Trees/Animal Genes : TreeFamELAVL4
HOGENOMP26378
Homologs : HomoloGeneELAVL4
Homology/Alignments : Family Browser (UCSC)ELAVL4
Gene fusions - Rearrangements
Fusion : MitelmanZCCHC11/ELAVL4 [1p32.3/1p33]  [t(1;1)(p32;p33)]  
Fusion PortalZCCHC11 1p32.3 ELAVL4 1p33 BRCA
Fusion : QuiverELAVL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELAVL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELAVL4
dbVarELAVL4
ClinVarELAVL4
1000_GenomesELAVL4 
Exome Variant ServerELAVL4
ExAC (Exome Aggregation Consortium)ENSG00000162374
GNOMAD BrowserENSG00000162374
Varsome BrowserELAVL4
Genetic variants : HAPMAP1996
Genomic Variants (DGV)ELAVL4 [DGVbeta]
DECIPHERELAVL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELAVL4 
Mutations
ICGC Data PortalELAVL4 
TCGA Data PortalELAVL4 
Broad Tumor PortalELAVL4
OASIS PortalELAVL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELAVL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DELAVL4
Mutations and Diseases : HGMDELAVL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ELAVL4
DgiDB (Drug Gene Interaction Database)ELAVL4
DoCM (Curated mutations)ELAVL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELAVL4 (select a term)
intoGenELAVL4
Cancer3DELAVL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM168360   
Orphanet
DisGeNETELAVL4
MedgenELAVL4
Genetic Testing Registry ELAVL4
NextProtP26378 [Medical]
TSGene1996
GENETestsELAVL4
Target ValidationELAVL4
Huge Navigator ELAVL4 [HugePedia]
snp3D : Map Gene to Disease1996
BioCentury BCIQELAVL4
ClinGenELAVL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1996
Chemical/Pharm GKB GenePA27743
Clinical trialELAVL4
Miscellaneous
canSAR (ICR)ELAVL4 (select the gene name)
DataMed IndexELAVL4
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELAVL4
EVEXELAVL4
GoPubMedELAVL4
iHOPELAVL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:41:48 CET 2019
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