ELK3 (ETS transcription factor ELK3)

2003-02-01  

Identity

HGNC
LOCATION
12q23.1
LOCUSID
ALIAS
ERP,NET,SAP-2,SAP2
FUSION GENES

Other Information

Locus ID:

NCBI: 2004
MIM: 600247
HGNC: 3325
Ensembl: ENSG00000111145

Variants:

dbSNP: 2004
ClinVar: 2004
TCGA: ENSG00000111145
COSMIC: ELK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111145ENST00000228741P41970
ENSG00000111145ENST00000228741A0A024RBE2
ENSG00000111145ENST00000547249F8VZQ0
ENSG00000111145ENST00000547860F8VUJ0
ENSG00000111145ENST00000549985H0YIH6
ENSG00000111145ENST00000552142G3V1Z7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
183165892008Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.23
254019282014The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.13
273016392016PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting autophagy.13
279594512017ELK3 promotes the migration and invasion of liver cancer stem cells by targeting HIF-1α.13
298927952018Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes.13
194831892009Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines.12
247195612014ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP.7
266374002015ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells.7
275565002016The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo.7

Citation

Dessen P

ELK3 (ETS transcription factor ELK3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40443/elk3