ELOVL6 (ELOVL fatty acid elongase 6)

2003-05-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
FACE,FAE,LCE
FUSION GENES

Other Information

Locus ID:

NCBI: 79071
MIM: 611546
HGNC: 15829
Ensembl: ENSG00000170522

Variants:

dbSNP: 79071
ClinVar: 79071
TCGA: ENSG00000170522
COSMIC: ELOVL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170522ENST00000302274Q9H5J4
ENSG00000170522ENST00000302274A0A024RDK5
ENSG00000170522ENST00000394607Q9H5J4
ENSG00000170522ENST00000394607A0A024RDK5
ENSG00000170522ENST00000503885D6RHI2
ENSG00000170522ENST00000506625D6RCU0
ENSG00000170522ENST00000514184D6RBP4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Fatty acid elongationKEGGko00062
Biosynthesis of unsaturated fatty acidsKEGGko01040
Fatty acid elongationKEGGhsa00062
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGhsa_M00415
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGM00415
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227531712012Elovl6 promotes nonalcoholic steatohepatitis.53
192596392009Elovl6: a new player in fatty acid metabolism and insulin sensitivity.37
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
241136222013Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice.22
247140862014Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.15
268628482016Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.15
217015772011ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.13
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
215446022011Increased elongase 6 and Δ9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis.8
297003192018Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression.5

Citation

Dessen P

ELOVL6 (ELOVL fatty acid elongase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40446/elovl6