EN1 (engrailed homeobox 1)

2003-05-01  

Identity

HGNC
EN1
LOCATION
2q14.2
LOCUSID
2019
ALIAS
ENDOVESLB

Other Information

Locus ID:

NCBI: 2019
MIM: 131290
HGNC: 3342
Ensembl: ENSG00000163064

Variants:

dbSNP: 2019
ClinVar: 2019
TCGA: ENSG00000163064
COSMIC: EN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163064ENST00000295206Q05925

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
263677942015Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.133
167306932006Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.128
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
241417792014Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function.26
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
193842952009Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease.18
152408572004Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development.17
193454442011Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease.16
193454442011Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease.16
246851772014The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed.15

Citation

Dessen P

EN1 (engrailed homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40450/en1