ENPEP (glutamyl aminopeptidase)

2003-05-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
APA,CD249,gp160
FUSION GENES

Other Information

Locus ID:

NCBI: 2028
MIM: 138297
HGNC: 3355
Ensembl: ENSG00000138792

Variants:

dbSNP: 2028
ClinVar: 2028
TCGA: ENSG00000138792
COSMIC: ENPEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138792ENST00000265162Q07075
ENSG00000138792ENST00000509344H0YA67

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240984522013miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.47
191874432009Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide.40
179991792008Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.17
181886972008The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain.16
179901032008New insights into the importance of aminopeptidase A in hypertension.11
193737772009Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.8
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
184105072008Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei.5
186777092008Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells.5

Citation

Dessen P

ENPEP (glutamyl aminopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40454/enpep