ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3)

2014-11-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
CD39L3,HB6,NTPDase-3

Other Information

Locus ID:

NCBI: 956
MIM: 603161
HGNC: 3365
Ensembl: ENSG00000168032

Variants:

dbSNP: 956
ClinVar: 956
TCGA: ENSG00000168032
COSMIC: ENTPD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168032ENST00000301825O75355
ENSG00000168032ENST00000439533C9J0J3
ENSG00000168032ENST00000445129O75355
ENSG00000168032ENST00000456402O75355
ENSG00000168032ENST00000647765A0A3B3IT06

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

References

Pubmed IDYearTitleCitations
159667242005Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling.14
191204512009Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 : partial characterization of the inhibitory epitope and potential applications.11
201900362010Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3.8
197438372009Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3.5
240850342013Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion.5
284722572017Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.4
260187282015Chondrogenic Differentiation of Human Mesenchymal Stem Cells Results in Substantial Changes of Ecto-Nucleotides Metabolism.0

Citation

Dessen P

ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62843/entpd3