ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive))

2007-02-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
CD39L4,NTPDase-5,PCPH
FUSION GENES

Other Information

Locus ID:

NCBI: 957
MIM: 603162
HGNC: 3367
Ensembl: ENSG00000187097

Variants:

dbSNP: 957
ClinVar: 957
TCGA: ENSG00000187097
COSMIC: ENTPD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187097ENST00000334696O75356
ENSG00000187097ENST00000334696A0A024R6D3
ENSG00000187097ENST00000553284G3V450
ENSG00000187097ENST00000555829H0YJH1
ENSG00000187097ENST00000556242G3V3Y0
ENSG00000187097ENST00000557325G3V4I0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210742482010The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.92
206016762010Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.50
279566232016Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.25
180068312007PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.22
191179922009PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.13
221692322011ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.8
124891102002Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.6
229929742012ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.6
164653632006PCPH expression is an early event in the development of testicular germ cell tumors.5
239214412013The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family.4

Citation

Dessen P

ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45704/entpd5