EPHA8 (EPH receptor A8)

2003-02-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
EEK,EK3,HEK3

Other Information

Locus ID:

NCBI: 2046
MIM: 176945
HGNC: 3391
Ensembl: ENSG00000070886

Variants:

dbSNP: 2046
ClinVar: 2046
TCGA: ENSG00000070886
COSMIC: EPHA8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070886ENST00000166244P29322
ENSG00000070886ENST00000374644P29322

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342784972021EphA8 inhibits cell apoptosis via AKT signaling and is associated with poor prognosis in breast cancer.2
342784972021EphA8 inhibits cell apoptosis via AKT signaling and is associated with poor prognosis in breast cancer.2
310260692019EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10.8
310260692019EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10.8
303003342018EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.4
303003342018EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.4
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.9
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.9
269890752016EphA8 is a prognostic marker for epithelial ovarian cancer.13
269890752016EphA8 is a prognostic marker for epithelial ovarian cancer.13
256830042015miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.32
256830042015miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.32
222919912012RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.7
222919912012RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.7
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2

Citation

Dessen P

EPHA8 (EPH receptor A8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40467/epha8