Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EPHB1 (EPH receptor B1)

Identity

Other namesELK
EPHT2
Hek6
NET
HGNC (Hugo) EPHB1
LocusID (NCBI) 2047
Location 3q22.2
Location_base_pair Starts at 134514099 and ends at 134979307 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHB1   3392
Entrez_Gene (NCBI)EPHB1  2047  EPH receptor B1
Cards
GeneCards (Weizmann)EPHB1
Ensembl (Hinxton)ENSG00000154928 [Gene_View]  chr3:134514099-134979307 [Contig_View]  EPHB1 [Vega]
AceView (NCBI)EPHB1
Genatlas (Paris)EPHB1
SOURCE (Stanford)NM_004441
Genomic and cartography
GoldenPath (UCSC)EPHB1  -  3q22.2   chr3:134514099-134979307 +  3q22.2   [Description]    (hg19-Feb_2009)
EnsemblEPHB1 - 3q22.2 [CytoView]
Mapping of homologs : NCBIEPHB1 [Mapview]
OMIM600600   
Gene and transcription
Genbank (Entrez)AF037333 AF037334 AK095305 AK291208 AK309741
RefSeq transcript (SRS)NM_004441
RefSeq transcript (Entrez)NM_004441
RefSeq genomic (SRS)AC_000135 NC_000003 NC_018914 NT_005612 NW_001838884 NW_004078013
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_005612 NW_001838884 NW_004078013
Consensus coding sequences : CCDS (NCBI)EPHB1
Cluster EST : UnigeneHs.116092 [ SRS ] Hs.116092 [ NCBI ]
CGAP (NCI)Hs.116092
Alternative Splicing : Fast-db (Paris)GSHG0021175
Alternative Splicing GalleryENSG00000154928
Gene ExpressionEPHB1 [ NCBI-GEO ]   EPHB1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54762 (SRS) P54762 (Uniprot)
NextProtP54762
With graphics : InterProP54762
Splice isoforms : SwissVarP54762(Swissvar)
Domaine pattern : Prosite (SRS)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (SRS)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domains : Interpro (EBI)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54762
Domain families : Pfam (SRS)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (Sanger)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam01404    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM2047
Blocks (Seattle)P54762
PDB (SRS)2DJS    2EAO   
PDB (PDBSum)2DJS    2EAO   
PDB (IMB)2DJS    2EAO   
PDB (RSDB)2DJS    2EAO   
Human Protein AtlasENSG00000154928
HPRD02790
IPIIPI00008315   IPI00947175   IPI00903258   IPI00219245   IPI00947014   IPI01019028   IPI00945114   
Protein Interaction databases
DIP (DOE-UCLA)P54762
IntAct (EBI)P54762
FunCoupENSG00000154928
REACTOMEEPHB1
Protein Interaction Database2047
BioGRIDEPHB1
InParanoidP54762
Interologous Interaction database P54762
IntegromeDBEPHB1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EPHB1
SNP (GeneSNP Utah)EPHB1
SNP : HGBaseEPHB1
Genetic variants : HAPMAPEPHB1
Somatic Mutations in Cancer : COSMICEPHB1 
CONAN: Copy Number AnalysisEPHB1 
Mutations and Diseases : HGMDEPHB1
OMIM600600   
GENETests600600   
Disease Genetic AssociationEPHB1
Huge Navigator EPHB1 [HugePedia]  EPHB1 [HugeCancerGEM]
Genomic VariantsEPHB1  EPHB1 [DGVbeta]
snp3D : Map Gene to Disease2047
General knowledge
Homologs : HomoloGeneEPHB1
Homology/Alignments : Family Browser (UCSC)EPHB1
Phylogenetic Trees/Animal Genes : TreeFamEPHB1
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD2047
Chemical/Pharm GKB GenePA27824
Clinical trialEPHB1
Cancer Resource (Charite)ENSG00000154928
Ontology : AmiGOangiogenesis  transmembrane-ephrin receptor activity  protein binding  ATP binding  integral to plasma membrane  axon guidance  axon guidance receptor activity  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  neurogenesis  establishment of cell polarity  axon  dendrite  retinal ganglion cell axon guidance  cell-substrate adhesion  early endosome membrane  membrane raft  regulation of JNK cascade  protein autophosphorylation  ephrin receptor signaling pathway  camera-type eye morphogenesis  detection of temperature stimulus involved in sensory perception of pain  positive regulation of synapse assembly  cell chemotaxis  dendritic spine development  dendritic spine morphogenesis  neural precursor cell proliferation  regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIangiogenesis  transmembrane-ephrin receptor activity  protein binding  ATP binding  integral to plasma membrane  axon guidance  axon guidance receptor activity  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  neurogenesis  establishment of cell polarity  axon  dendrite  retinal ganglion cell axon guidance  cell-substrate adhesion  early endosome membrane  membrane raft  regulation of JNK cascade  protein autophosphorylation  ephrin receptor signaling pathway  camera-type eye morphogenesis  detection of temperature stimulus involved in sensory perception of pain  positive regulation of synapse assembly  cell chemotaxis  dendritic spine development  dendritic spine morphogenesis  neural precursor cell proliferation  regulation of ERK1 and ERK2 cascade  
Pathways : BIOCARTAEph Kinases and ephrins support platelet aggregation [Genes]   
Pathways : KEGGAxon guidance
Other databases
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
PubGeneEPHB1
iHOPEPHB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:02 CEST 2013
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