EPHB3 (EPH receptor B3)

2003-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
EK2,ETK2,HEK2,TYRO6
FUSION GENES

Other Information

Locus ID:

NCBI: 2049
MIM: 601839
HGNC: 3394
Ensembl: ENSG00000182580

Variants:

dbSNP: 2049
ClinVar: 2049
TCGA: ENSG00000182580
COSMIC: EPHB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182580ENST00000330394P54753

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381508662024EphB3 protein is a potential ancillary diagnostic biomarker for thyroid cancers.0
381508662024EphB3 protein is a potential ancillary diagnostic biomarker for thyroid cancers.0
370046042023Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis.0
370046042023Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis.0
342965452021Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.3
342965452021Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.3
305358642020Receptor Tyrosine Kinase EphB3: a Prognostic Indicator in Colorectal Carcinoma.7
322949812020Expression Profile and Prognostic Significance of EPHB3 in Colorectal Cancer.7
305358642020Receptor Tyrosine Kinase EphB3: a Prognostic Indicator in Colorectal Carcinoma.7
322949812020Expression Profile and Prognostic Significance of EPHB3 in Colorectal Cancer.7
304085512019EZH2-mediated epigenetic suppression of EphB3 inhibits gastric cancer proliferation and metastasis by affecting E-cadherin and vimentin expression.14
304085512019EZH2-mediated epigenetic suppression of EphB3 inhibits gastric cancer proliferation and metastasis by affecting E-cadherin and vimentin expression.14
296202302018Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.21
297897132018Upregulation of the long noncoding RNA FOXD2-AS1 promotes carcinogenesis by epigenetically silencing EphB3 through EZH2 and LSD1, and predicts poor prognosis in gastric cancer.60
299704822018Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor.6

Citation

Dessen P

EPHB3 (EPH receptor B3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40469/ephb3