EPHB4 (EPH receptor B4)

2003-02-01  

Identity

HGNC
EPHB4
LOCATION
7q22.1
LOCUSID
2050
ALIAS
CMAVM2,HFASD,HTK,LMPHM7,MYK1,TYRO11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2050
MIM: 600011
HGNC: 3395
Ensembl: ENSG00000196411

Variants:

dbSNP: 2050
ClinVar: 2050
TCGA: ENSG00000196411
COSMIC: EPHB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196411ENST00000358173P54760
ENSG00000196411ENST00000358173Q541P7
ENSG00000196411ENST00000360620Q96L35
ENSG00000196411ENST00000616502P54760

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157223422005EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.57
164249042006EphB4 controls blood vascular morphogenesis during postnatal angiogenesis.52
193668062009Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.49
219354092011Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.49
122351512002Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.47
127343952003Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.46
159302802005EphB4 expression and biological significance in prostate cancer.45
172349652007Notch ligand Delta-like 1 is essential for postnatal arteriogenesis.44
147644522004Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation.42
168679922006Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.42

Citation

Dessen P

EPHB4 (EPH receptor B4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40470/ephb4