Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EPRS1 (glutamyl-prolyl-tRNA synthetase 1)

Identity

Alias_namesQPRS
QARS
EPRS
glutamyl-prolyl-tRNA synthetase
Alias_symbol (synonym)EARS
PARS
GLUPRORS
Other aliasHLD15
PIG32
HGNC (Hugo) EPRS1
LocusID (NCBI) 2058
Atlas_Id 58163
Location 1q41  [Link to chromosome band 1q41]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)EPRS1   3418
Cards
Entrez_Gene (NCBI)EPRS1  2058  glutamyl-prolyl-tRNA synthetase 1
AliasesEARS; EPRS; GLUPRORS; HLD15; 
PARS; PIG32; QARS; QPRS
GeneCards (Weizmann)EPRS1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  EPRS1 [Vega]
TCGA cBioPortalEPRS1
AceView (NCBI)EPRS1
Genatlas (Paris)EPRS1
WikiGenes2058
SOURCE (Princeton)EPRS1
Genetics Home Reference (NIH)EPRS1
Genomic and cartography
GoldenPath hg38 (UCSC)EPRS1  -  
GoldenPath hg19 (UCSC)EPRS1  -  
GoldenPathEPRS1 - [CytoView hg19]  EPRS1 - [CytoView hg38]
Mapping of homologs : NCBIEPRS1 [Mapview hg19]  EPRS1 [Mapview hg38]
OMIM138295   617951   
Gene and transcription
Genbank (Entrez)AA196283 AK296755 AK298192 AK307534 AY493416
RefSeq transcript (Entrez)NM_004446
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPRS1
Cluster EST : UnigeneHs.497788 [ NCBI ]
CGAP (NCI)Hs.497788
Gene ExpressionEPRS1 [ NCBI-GEO ]   EPRS1 [ EBI - ARRAY_EXPRESS ]   EPRS1 [ SEEK ]   EPRS1 [ MEM ]
Gene Expression Viewer (FireBrowse)EPRS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2058
GTEX Portal (Tissue expression)EPRS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07814   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07814  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07814
Splice isoforms : SwissVarP07814
Catalytic activity : Enzyme6.1.1.17 [ Enzyme-Expasy ]   6.1.1.176.1.1.17 [ IntEnz-EBI ]   6.1.1.17 [ BRENDA ]   6.1.1.17 [ KEGG ]   
PhosPhoSitePlusP07814
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_I_CS    aa-tRNA-synth_II    Anticodon-bd    Anticodon-bd_dom_sf    Glu-tRNA-synth_arc/euk    Glu/Gln-tRNA-synth    Glu/Gln-tRNA-synth_Ib_cat-dom    Glu/Gln-tRNA-synth_Ib_codon-bd    Glutathione-S-Trfase_C_sf    GST_C    Pro-tRNA-ligase_IIa_arc-type    Pro-tRNA_ligase_II_C    Pro-tRNA_synth_II    ProRS_core_arch_euk    Rbsml_L25/Gln-tRNA_synth_N    Ribosomal_L25/Gln-tRNA_synth    Rossmann-like_a/b/a_fold    S15_NS1_RNA-bd    WHEP-TRS_dom   
Domain families : Pfam (Sanger)GST_C (PF00043)    HGTP_anticodon (PF03129)    ProRS-C_1 (PF09180)    tRNA-synt_1c (PF00749)    tRNA-synt_1c_C (PF03950)    tRNA-synt_2b (PF00587)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam00043    pfam03129    pfam09180    pfam00749    pfam03950    pfam00587    pfam00458   
Domain families : Smart (EMBL)ProRS-C_1 (SM00946)  WHEP-TRS (SM00991)  
Conserved Domain (NCBI)EPRS1
DMDM Disease mutations2058
Blocks (Seattle)EPRS1
PDB (RSDB)1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
PDB Europe1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
PDB (PDBSum)1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
PDB (IMB)1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
Structural Biology KnowledgeBase1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
SCOP (Structural Classification of Proteins)1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
CATH (Classification of proteins structures)1FYJ    4HVC    4K86    4K87    4K88    5A1N    5A34    5A5H    5BMU    5V58    5VAD   
SuperfamilyP07814
Peptide AtlasP07814
IPIIPI00013452   IPI00909383   IPI01009785   
Protein Interaction databases
DIP (DOE-UCLA)P07814
IntAct (EBI)P07814
BioGRIDEPRS1
STRING (EMBL)EPRS1
ZODIACEPRS1
Ontologies - Pathways
QuickGOP07814
Ontology : AmiGOglutamate-tRNA ligase activity  proline-tRNA ligase activity  proline-tRNA ligase activity  proline-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  tRNA aminoacylation for protein translation  glutamyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  zinc ion binding  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  negative regulation of translation  negative regulation of translation  cellular response to insulin stimulus  RNA stem-loop binding  identical protein binding  protein homodimerization activity  long-chain fatty acid import  GTPase binding  protein-containing complex assembly  cellular response to interferon-gamma  GAIT complex  regulation of long-chain fatty acid import into cell  ribonucleoprotein complex  
Ontology : EGO-EBIglutamate-tRNA ligase activity  proline-tRNA ligase activity  proline-tRNA ligase activity  proline-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  tRNA aminoacylation for protein translation  glutamyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  zinc ion binding  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  negative regulation of translation  negative regulation of translation  cellular response to insulin stimulus  RNA stem-loop binding  identical protein binding  protein homodimerization activity  long-chain fatty acid import  GTPase binding  protein-containing complex assembly  cellular response to interferon-gamma  GAIT complex  regulation of long-chain fatty acid import into cell  ribonucleoprotein complex  
NDEx NetworkEPRS1
Atlas of Cancer Signalling NetworkEPRS1
Wikipedia pathwaysEPRS1
Orthology - Evolution
OrthoDB2058
Phylogenetic Trees/Animal Genes : TreeFamEPRS1
HOGENOMP07814
Homologs : HomoloGeneEPRS1
Homology/Alignments : Family Browser (UCSC)EPRS1
Gene fusions - Rearrangements
Fusion : QuiverEPRS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPRS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPRS1
dbVarEPRS1
ClinVarEPRS1
1000_GenomesEPRS1 
Exome Variant ServerEPRS1
Varsome BrowserEPRS1
Genetic variants : HAPMAP2058
Genomic Variants (DGV)EPRS1 [DGVbeta]
DECIPHEREPRS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPRS1 
Mutations
ICGC Data PortalEPRS1 
TCGA Data PortalEPRS1 
Broad Tumor PortalEPRS1
OASIS PortalEPRS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDEPRS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPRS1
DgiDB (Drug Gene Interaction Database)EPRS1
DoCM (Curated mutations)EPRS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPRS1 (select a term)
intoGenEPRS1
Cancer3DEPRS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138295    617951   
Orphanet
DisGeNETEPRS1
MedgenEPRS1
Genetic Testing Registry EPRS1
NextProtP07814 [Medical]
TSGene2058
GENETestsEPRS1
Target ValidationEPRS1
Huge Navigator EPRS1 [HugePedia]
snp3D : Map Gene to Disease2058
BioCentury BCIQEPRS1
ClinGenEPRS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2058
Chemical/Pharm GKB GenePA27837
Clinical trialEPRS1
Miscellaneous
canSAR (ICR)EPRS1 (select the gene name)
DataMed IndexEPRS1
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPRS1
EVEXEPRS1
GoPubMedEPRS1
iHOPEPRS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:42:11 CET 2019

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