Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EPX (eosinophil peroxidase)

Identity

Alias (NCBI)EPO
EPP
EPX-PEN
EPXD
HGNC (Hugo) EPX
HGNC Alias symbEPO
EPP
EPX-PEN
LocusID (NCBI) 8288
Atlas_Id 56108
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58192726 and ends at 58205174 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPX   3423
Cards
Entrez_Gene (NCBI)EPX  8288  eosinophil peroxidase
AliasesEPO; EPP; EPX-PEN; EPXD
GeneCards (Weizmann)EPX
Ensembl hg19 (Hinxton)ENSG00000121053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121053 [Gene_View]  ENSG00000121053 [Sequence]  chr17:58192726-58205174 [Contig_View]  EPX [Vega]
ICGC DataPortalENSG00000121053
TCGA cBioPortalEPX
AceView (NCBI)EPX
Genatlas (Paris)EPX
WikiGenes8288
SOURCE (Princeton)EPX
Genetics Home Reference (NIH)EPX
Genomic and cartography
GoldenPath hg38 (UCSC)EPX  -     chr17:58192726-58205174 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPX  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathEPX - 17q22 [CytoView hg19]  EPX - 17q22 [CytoView hg38]
ImmunoBaseENSG00000121053
genome Data Viewer NCBIEPX [Mapview hg19]  
OMIM131399   261500   
Gene and transcription
Genbank (Entrez)AJ705406 AL597635 BM147889 X14346
RefSeq transcript (Entrez)NM_000502
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPX
Alternative Splicing GalleryENSG00000121053
Gene ExpressionEPX [ NCBI-GEO ]   EPX [ EBI - ARRAY_EXPRESS ]   EPX [ SEEK ]   EPX [ MEM ]
Gene Expression Viewer (FireBrowse)EPX [ Firebrowse - Broad ]
GenevisibleExpression of EPX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8288
GTEX Portal (Tissue expression)EPX
Human Protein AtlasENSG00000121053-EPX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11678   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11678  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11678
Splice isoforms : SwissVarP11678
Catalytic activity : Enzyme1.11.1.7 [ Enzyme-Expasy ]   1.11.1.71.11.1.7 [ IntEnz-EBI ]   1.11.1.7 [ BRENDA ]   1.11.1.7 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP11678
Domaine pattern : Prosite (Expaxy)PEROXIDASE_1 (PS00435)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)EPX/EPO    Haem_peroxidase_animal    Haem_peroxidase_sf    Haem_peroxidase_sf_animal   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)   
Domain families : Pfam (NCBI)pfam03098   
Conserved Domain (NCBI)EPX
DMDM Disease mutations8288
Blocks (Seattle)EPX
SuperfamilyP11678
Human Protein Atlas [tissue]ENSG00000121053-EPX [tissue]
Peptide AtlasP11678
HPRD00576
IPIIPI00006690   
Protein Interaction databases
DIP (DOE-UCLA)P11678
IntAct (EBI)P11678
FunCoupENSG00000121053
BioGRIDEPX
STRING (EMBL)EPX
ZODIACEPX
Ontologies - Pathways
QuickGOP11678
Ontology : AmiGOdefense response to nematode  peroxidase activity  extracellular region  extracellular space  response to oxidative stress  heme binding  negative regulation of interleukin-10 production  negative regulation of interleukin-5 production  positive regulation of interleukin-4 production  secretory granule lumen  defense response to bacterium  hydrogen peroxide catabolic process  neutrophil degranulation  metal ion binding  oxidation-reduction process  extracellular exosome  eosinophil migration  cellular oxidant detoxification  
Ontology : EGO-EBIdefense response to nematode  peroxidase activity  extracellular region  extracellular space  response to oxidative stress  heme binding  negative regulation of interleukin-10 production  negative regulation of interleukin-5 production  positive regulation of interleukin-4 production  secretory granule lumen  defense response to bacterium  hydrogen peroxide catabolic process  neutrophil degranulation  metal ion binding  oxidation-reduction process  extracellular exosome  eosinophil migration  cellular oxidant detoxification  
Pathways : KEGGAsthma   
NDEx NetworkEPX
Atlas of Cancer Signalling NetworkEPX
Wikipedia pathwaysEPX
Orthology - Evolution
OrthoDB8288
GeneTree (enSembl)ENSG00000121053
Phylogenetic Trees/Animal Genes : TreeFamEPX
HOGENOMP11678
Homologs : HomoloGeneEPX
Homology/Alignments : Family Browser (UCSC)EPX
Gene fusions - Rearrangements
Fusion : QuiverEPX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPX
dbVarEPX
ClinVarEPX
1000_GenomesEPX 
Exome Variant ServerEPX
GNOMAD BrowserENSG00000121053
Varsome BrowserEPX
Genetic variants : HAPMAP8288
Genomic Variants (DGV)EPX [DGVbeta]
DECIPHEREPX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPX 
Mutations
ICGC Data PortalEPX 
TCGA Data PortalEPX 
Broad Tumor PortalEPX
OASIS PortalEPX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEPX
Mutations and Diseases : HGMDEPX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPX
DgiDB (Drug Gene Interaction Database)EPX
DoCM (Curated mutations)EPX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPX (select a term)
intoGenEPX
Cancer3DEPX(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131399    261500   
Orphanet
DisGeNETEPX
MedgenEPX
Genetic Testing Registry EPX
NextProtP11678 [Medical]
TSGene8288
GENETestsEPX
Target ValidationEPX
Huge Navigator EPX [HugePedia]
snp3D : Map Gene to Disease8288
BioCentury BCIQEPX
ClinGenEPX
Clinical trials, drugs, therapy
Protein Interactions : CTD8288
Pharm GKB GenePA27841
Clinical trialEPX
Miscellaneous
canSAR (ICR)EPX (select the gene name)
HarmonizomeEPX
DataMed IndexEPX
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPX
EVEXEPX
GoPubMedEPX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:12:19 CEST 2020
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