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ERBB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4)

Identity

Other namesALS19
HER4
p180erbB4
HGNC (Hugo) ERBB4
LocusID (NCBI) 2066
Location 2q34
Location_base_pair Starts at 212240442 and ends at 213403352 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ERBB4   3432
Cards
Entrez_Gene (NCBI)ERBB4  2066  v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
GeneCards (Weizmann)ERBB4
Ensembl (Hinxton)ENSG00000178568 [Gene_View]  chr2:212240442-213403352 [Contig_View]  ERBB4 [Vega]
AceView (NCBI)ERBB4
Genatlas (Paris)ERBB4
WikiGenes2066
SOURCE (Princeton)NM_001042599 NM_005235
Genomic and cartography
GoldenPath (UCSC)ERBB4  -  2q34   chr2:212240442-213403352 -  2q34   [Description]    (hg19-Feb_2009)
EnsemblERBB4 - 2q34 [CytoView]
Mapping of homologs : NCBIERBB4 [Mapview]
OMIM600543   
Gene and transcription
Genbank (Entrez)AB209697 AF007153 AI793060 AK024204 AK126298
RefSeq transcript (Entrez)NM_001042599 NM_005235
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_011805 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)ERBB4
Cluster EST : UnigeneHs.390729 [ NCBI ]
CGAP (NCI)Hs.390729
Alternative Splicing : Fast-db (Paris)GSHG0033365
Alternative Splicing GalleryENSG00000178568
Gene ExpressionERBB4 [ NCBI-GEO ]     ERBB4 [ SEEK ]   ERBB4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15303 (Uniprot)
NextProtQ15303  [Medical]
With graphics : InterProQ15303
Splice isoforms : SwissVarQ15303 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)EGF_rcpt_L    Furin-like_Cys-rich_dom    Furin_repeat    Growth_fac_rcpt_N_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_EGF/ERB/XmrK_rcpt   
Related proteins : CluSTrQ15303
Domain families : Pfam (Sanger)Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FU (SM00261)  TyrKc (SM00219)  
DMDM Disease mutations2066
Blocks (Seattle)Q15303
PDB (SRS)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (PDBSum)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (IMB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (RSDB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
Human Protein AtlasENSG00000178568
Peptide AtlasQ15303
HPRD02767
IPIIPI00016371   IPI00215722   IPI00816395   IPI00969544   IPI00927238   
Protein Interaction databases
DIP (DOE-UCLA)Q15303
IntAct (EBI)Q15303
FunCoupENSG00000178568
BioGRIDERBB4
InParanoidQ15303
Interologous Interaction database Q15303
IntegromeDBERBB4
STRING (EMBL)ERBB4
Ontologies - Pathways
Ontology : AmiGOneural crest cell migration  positive regulation of protein phosphorylation  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  nervous system development  heart development  lactation  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  embryonic pattern specification  integral to membrane  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  Fc-epsilon receptor signaling pathway  positive regulation of tyrosine phosphorylation of Stat5 protein  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of phosphatidylinositol 3-kinase activity  mitochondrial fragmentation involved in apoptotic process  transcription regulatory region DNA binding  innate immune response  cell fate commitment  positive regulation of transcription, DNA-dependent  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  positive regulation of STAT protein import into nucleus  
Ontology : EGO-EBIneural crest cell migration  positive regulation of protein phosphorylation  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  nervous system development  heart development  lactation  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  embryonic pattern specification  integral to membrane  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  Fc-epsilon receptor signaling pathway  positive regulation of tyrosine phosphorylation of Stat5 protein  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of phosphatidylinositol 3-kinase activity  mitochondrial fragmentation involved in apoptotic process  transcription regulatory region DNA binding  innate immune response  cell fate commitment  positive regulation of transcription, DNA-dependent  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  positive regulation of STAT protein import into nucleus  
Pathways : BIOCARTAg-Secretase mediated ErbB4 Signaling [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGErbB signaling pathway    Calcium signaling pathway    Endocytosis    Proteoglycans in cancer   
REACTOMEERBB4
Protein Interaction DatabaseERBB4
Wikipedia pathwaysERBB4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ERBB4
SNP (GeneSNP Utah)ERBB4
SNP : HGBaseERBB4
Genetic variants : HAPMAPERBB4
1000_GenomesERBB4 
ICGC programENSG00000178568 
Somatic Mutations in Cancer : COSMICERBB4 
CONAN: Copy Number AnalysisERBB4 
Mutations and Diseases : HGMDERBB4
OMIM600543   
GENETestsERBB4
Disease Genetic AssociationERBB4
Huge Navigator ERBB4 [HugePedia]  ERBB4 [HugeCancerGEM]
Genomic VariantsERBB4  ERBB4 [DGVbeta]
Exome VariantERBB4
dbVarERBB4
ClinVarERBB4
snp3D : Map Gene to Disease2066
General knowledge
Homologs : HomoloGeneERBB4
Homology/Alignments : Family Browser (UCSC)ERBB4
Phylogenetic Trees/Animal Genes : TreeFamERBB4
Chemical/Protein Interactions : CTD2066
Chemical/Pharm GKB GenePA27847
Clinical trialERBB4
Cancer Resource (Charite)ENSG00000178568
Other databases
Probes
Litterature
PubMed197 Pubmed reference(s) in Entrez
CoreMineERBB4
iHOPERBB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:54:22 CEST 2014

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