| Nomenclature | | HGNC (Hugo) | ERBB4 3432 |
| Entrez_Gene (NCBI) | ERBB4 2066 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
| Cards | | GeneCards (Weizmann) | ERBB4 |
| Ensembl (Hinxton) | ENSG00000178568 [Gene_View] chr2:212240442-213403352 [Contig_View] ERBB4 [Vega] |
| AceView (NCBI) | ERBB4 |
| Genatlas (Paris) | ERBB4 |
| SOURCE (Stanford) | NM_001042599 NM_005235 |
| Genomic and cartography | | GoldenPath (UCSC) | ERBB4 - 2q34 chr2:212240442-213403352 - 2q34 [Description] (hg19-Feb_2009) |
| Ensembl | ERBB4 - 2q34 [CytoView] |
| Mapping of homologs : NCBI | ERBB4 [Mapview] |
| OMIM | 600543 |
| Gene and transcription |
| Genbank (Entrez) | AB209697 AF007153 AI793060 AK024204 AK126298 |
| RefSeq transcript (SRS) | NM_001042599 NM_005235 |
| RefSeq transcript (Entrez) | NM_001042599 NM_005235 |
| RefSeq genomic (SRS) | AC_000134 NC_000002 NC_018913 NG_011805 NT_005403 NW_001838863 NW_004078008 |
| RefSeq genomic (Entrez) | AC_000134 NC_000002 NC_018913 NG_011805 NT_005403 NW_001838863 NW_004078008 |
| Consensus coding sequences : CCDS (NCBI) | ERBB4 |
| Cluster EST : Unigene | Hs.390729 [ SRS ] Hs.390729 [ NCBI ] |
| CGAP (NCI) | Hs.390729 |
| Alternative Splicing : Fast-db (Paris) | GSHG0033365 |
| Alternative Splicing Gallery | ENSG00000178568 |
| Gene Expression | ERBB4 [ NCBI-GEO ] ERBB4 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q15303 (SRS) Q15303 (Uniprot) |
| NextProt | Q15303 |
| With graphics : InterPro | Q15303 |
| Splice isoforms : SwissVar | Q15303(Swissvar) |
| Domaine pattern : Prosite (SRS) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_TYR (PS00109) |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_TYR (PS00109) |
| Domains : Interpro (SRS) | EGF_rcpt_L Furin-like_Cys-rich_dom Furin_repeat Growth_fac_rcpt Kinase-like_dom Prot_kinase_cat_dom Protein_kinase_ATP_BS Ser-Thr/Tyr_kinase_cat_dom Tyr_kinase_AS Tyr_kinase_cat_dom Tyr_kinase_EGF/ERB/XmrK_rcpt |
| Domains : Interpro (EBI) | EGF_rcpt_L Furin-like_Cys-rich_dom Furin_repeat Growth_fac_rcpt Kinase-like_dom Prot_kinase_cat_dom Protein_kinase_ATP_BS Ser-Thr/Tyr_kinase_cat_dom Tyr_kinase_AS Tyr_kinase_cat_dom Tyr_kinase_EGF/ERB/XmrK_rcpt |
| Related proteins : CluSTr | Q15303 |
| Domain families : Pfam (SRS) | Furin-like (PF00757) Pkinase_Tyr (PF07714) Recep_L_domain (PF01030) |
| Domain families : Pfam (Sanger) | Furin-like (PF00757) Pkinase_Tyr (PF07714) Recep_L_domain (PF01030) |
| Domain families : Pfam (NCBI) | pfam00757 pfam07714 pfam01030 |
| Domain families : Smart (EMBL) | FU (SM00261) TyrKc (SM00219) |
| DMDM | 2066 |
| Blocks (Seattle) | Q15303 |
| PDB (SRS) | 2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U |
| PDB (PDBSum) | 2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U |
| PDB (IMB) | 2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U |
| PDB (RSDB) | 2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U |
| Human Protein Atlas | ENSG00000178568 |
| HPRD | 02767 |
| IPI | IPI00016371 IPI00215722 IPI00816395 IPI00969544 IPI00927238 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q15303 |
| IntAct (EBI) | Q15303 |
| FunCoup | ENSG00000178568 |
| REACTOME | ERBB4 |
| Protein Interaction Database | 2066 |
| BioGRID | ERBB4 |
| InParanoid | Q15303 |
| Interologous Interaction database | Q15303 |
| IntegromeDB | ERBB4 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | ERBB4 |
| SNP (GeneSNP Utah) | ERBB4 |
| SNP : HGBase | ERBB4 |
| Genetic variants : HAPMAP | ERBB4 |
| Somatic Mutations in Cancer : COSMIC | ERBB4 |
| CONAN: Copy Number Analysis | ERBB4 |
| Mutations and Diseases : HGMD | ERBB4 |
| OMIM | 600543 |
| GENETests | 600543 |
| Disease Genetic Association | ERBB4 |
| Huge Navigator |
ERBB4 [HugePedia] ERBB4 [HugeCancerGEM] |
| Genomic Variants | ERBB4 ERBB4 [DGVbeta] |
| snp3D : Map Gene to Disease | 2066 |
| General knowledge |
|---|
| Homologs : HomoloGene | ERBB4 |
| Homology/Alignments : Family Browser (UCSC) | ERBB4 |
| Phylogenetic Trees/Animal Genes : TreeFam | ERBB4 |
| Catalytic activity : Enzyme | 2.7.10.1 [ Enzyme-Expasy ] 2.7.10.1 [ Enzyme-SRS ] 2.7.10.1 [ IntEnz-EBI ] 2.7.10.1 [ BRENDA ] 2.7.10.1 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 2066 |
| Chemical/Pharm GKB Gene | PA27847 |
| Clinical trial | ERBB4 |
| Cancer Resource (Charite) | ENSG00000178568 |
| Ontology : AmiGO | neural crest cell migration positive regulation of protein phosphorylation protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity epidermal growth factor receptor binding protein binding ATP binding extracellular region nucleus nucleoplasm nucleolus cytoplasm mitochondrion mitochondrial matrix cytosol plasma membrane caveola transcription, DNA-dependent apoptotic process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway nervous system development heart development lactation cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation embryonic pattern specification postsynaptic density integral to membrane basolateral plasma membrane cell migration peptidyl-tyrosine phosphorylation central nervous system morphogenesis olfactory bulb interneuron differentiation regulation of cell migration positive regulation of cell migration positive regulation of synaptic transmission, GABAergic response to progesterone stimulus response to drug positive regulation of tyrosine phosphorylation of Stat5 protein response to hydrogen peroxide protein homodimerization activity negative regulation of apoptotic process surfactant homeostasis positive regulation of phosphatidylinositol 3-kinase activity positive regulation of phosphatidylinositol 3-kinase activity transcription regulatory region DNA binding cell fate commitment positive regulation of transcription, DNA-dependent positive regulation of glucose import protein autophosphorylation positive regulation of epithelial cell proliferation positive regulation of cardiac muscle cell proliferation synapse maturation mammary gland epithelial cell differentiation mammary gland alveolus development cardiac muscle tissue regeneration positive regulation of ERK1 and ERK2 cascade positive regulation of STAT protein import into nucleus |
| Ontology : EGO-EBI | neural crest cell migration positive regulation of protein phosphorylation protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity epidermal growth factor receptor binding protein binding ATP binding extracellular region nucleus nucleoplasm nucleolus cytoplasm mitochondrion mitochondrial matrix cytosol plasma membrane caveola transcription, DNA-dependent apoptotic process signal transduction transmembrane receptor protein tyrosine kinase signaling pathway nervous system development heart development lactation cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation embryonic pattern specification postsynaptic density integral to membrane basolateral plasma membrane cell migration peptidyl-tyrosine phosphorylation central nervous system morphogenesis olfactory bulb interneuron differentiation regulation of cell migration positive regulation of cell migration positive regulation of synaptic transmission, GABAergic response to progesterone stimulus response to drug positive regulation of tyrosine phosphorylation of Stat5 protein response to hydrogen peroxide protein homodimerization activity negative regulation of apoptotic process surfactant homeostasis positive regulation of phosphatidylinositol 3-kinase activity positive regulation of phosphatidylinositol 3-kinase activity transcription regulatory region DNA binding cell fate commitment positive regulation of transcription, DNA-dependent positive regulation of glucose import protein autophosphorylation positive regulation of epithelial cell proliferation positive regulation of cardiac muscle cell proliferation synapse maturation mammary gland epithelial cell differentiation mammary gland alveolus development cardiac muscle tissue regeneration positive regulation of ERK1 and ERK2 cascade positive regulation of STAT protein import into nucleus |
| Pathways : BIOCARTA | g-Secretase mediated ErbB4 Signaling [Genes] Role of ERBB2 in Signal Transduction and Oncology [Genes] |
| Pathways : KEGG | Dorso-ventral axis formationCalcium signaling pathway |
| Other databases | | Probes |
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| Litterature | | PubMed | 179 Pubmed reference(s) in Entrez |
| PubGene | ERBB4 |
| iHOP | ERBB4 |
