Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ERBB4 (erb-b2 receptor tyrosine kinase 4)

Identity

Other namesALS19
HER4
p180erbB4
HGNC (Hugo) ERBB4
LocusID (NCBI) 2066
Atlas_Id 40480
Location 2q34
Location_base_pair Starts at 212240442 and ends at 213403352 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATAD2 (8q24.13) / ERBB4 (2q34)ATP2B4 (1q32.1) / ERBB4 (2q34)ERBB4 (2q34) / CSDE1 (1p13.2)
ERBB4 (2q34) / FUS (16p11.2)ERBB4 (2q34) / IKZF2 (2q34)ERBB4 (2q34) / KCNAB1 (3q25.31)
EZR (6q25.3) / ERBB4 (2q34)KANSL1L (2q34) / ERBB4 (2q34)LCLAT1 (2p23.1) / ERBB4 (2q34)
NFIB (9p23) / ERBB4 (2q34)ATAD2 8q24.13 / ERBB4 2q34ATP2B4 1q32.1 / ERBB4 2q34
C2orf67 ERBB4 2q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Colon: Colorectal adenocarcinoma

External links

Nomenclature
HGNC (Hugo)ERBB4   3432
Cards
Entrez_Gene (NCBI)ERBB4  2066  erb-b2 receptor tyrosine kinase 4
AliasesALS19; HER4; p180erbB4
GeneCards (Weizmann)ERBB4
Ensembl hg19 (Hinxton)ENSG00000178568 [Gene_View]  chr2:212240442-213403352 [Contig_View]  ERBB4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178568 [Gene_View]  chr2:212240442-213403352 [Contig_View]  ERBB4 [Vega]
ICGC DataPortalENSG00000178568
TCGA cBioPortalERBB4
AceView (NCBI)ERBB4
Genatlas (Paris)ERBB4
WikiGenes2066
SOURCE (Princeton)ERBB4
Genomic and cartography
GoldenPath hg19 (UCSC)ERBB4  -     chr2:212240442-213403352 -  2q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ERBB4  -     2q34   [Description]    (hg38-Dec_2013)
EnsemblERBB4 - 2q34 [CytoView hg19]  ERBB4 - 2q34 [CytoView hg38]
Mapping of homologs : NCBIERBB4 [Mapview hg19]  ERBB4 [Mapview hg38]
OMIM600543   615515   
Gene and transcription
Genbank (Entrez)AB209697 AF007153 AI793060 AK024204 AK126298
RefSeq transcript (Entrez)NM_001042599 NM_005235
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_011805 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)ERBB4
Cluster EST : UnigeneHs.390729 [ NCBI ]
CGAP (NCI)Hs.390729
Alternative Splicing GalleryENSG00000178568
Gene ExpressionERBB4 [ NCBI-GEO ]   ERBB4 [ EBI - ARRAY_EXPRESS ]   ERBB4 [ SEEK ]   ERBB4 [ MEM ]
Gene Expression Viewer (FireBrowse)ERBB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2066
GTEX Portal (Tissue expression)ERBB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15303 (Uniprot)
NextProtQ15303  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15303
Splice isoforms : SwissVarQ15303 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusQ15303
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Furin-like_Cys-rich_dom    Furin_repeat    GF_recep_IV    Growth_fac_rcpt_    Kinase-like_dom    L_dom-like    Prot_kinase_dom    Protein_kinase_ATP_BS    Rcpt_L-dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_EGF/ERB/XmrK_rcpt   
Domain families : Pfam (Sanger)Furin-like (PF00757)    GF_recep_IV (PF14843)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam14843    pfam07714    pfam01030   
Domain families : Smart (EMBL)FU (SM00261)  TyrKc (SM00219)  
DMDM Disease mutations2066
Blocks (Seattle)ERBB4
PDB (SRS)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (PDBSum)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (IMB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
PDB (RSDB)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
Structural Biology KnowledgeBase2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
SCOP (Structural Classification of Proteins)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
CATH (Classification of proteins structures)2AHX    2L2T    2LCX    2R4B    3BBT    3BBW    3BCE    3U2P    3U7U    3U9U   
SuperfamilyQ15303
Human Protein AtlasENSG00000178568
Peptide AtlasQ15303
HPRD02767
IPIIPI00016371   IPI00215722   IPI00816395   IPI00969544   IPI00927238   
Protein Interaction databases
DIP (DOE-UCLA)Q15303
IntAct (EBI)Q15303
FunCoupENSG00000178568
BioGRIDERBB4
STRING (EMBL)ERBB4
ZODIACERBB4
Ontologies - Pathways
QuickGOQ15303
Ontology : AmiGOMAPK cascade  neural crest cell migration  positive regulation of protein phosphorylation  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  nervous system development  heart development  lactation  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  embryonic pattern specification  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  ERBB2 signaling pathway  positive regulation of tyrosine phosphorylation of Stat5 protein  protein homodimerization activity  negative regulation of apoptotic process  receptor complex  positive regulation of GTPase activity  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of phosphatidylinositol 3-kinase activity  mitochondrial fragmentation involved in apoptotic process  transcription regulatory region DNA binding  cell fate commitment  positive regulation of transcription, DNA-templated  protein autophosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of STAT protein import into nucleus  negative regulation of neuron migration  
Ontology : EGO-EBIMAPK cascade  neural crest cell migration  positive regulation of protein phosphorylation  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  nervous system development  heart development  lactation  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  embryonic pattern specification  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  basolateral plasma membrane  cell migration  peptidyl-tyrosine phosphorylation  central nervous system morphogenesis  olfactory bulb interneuron differentiation  regulation of cell migration  ERBB2 signaling pathway  positive regulation of tyrosine phosphorylation of Stat5 protein  protein homodimerization activity  negative regulation of apoptotic process  receptor complex  positive regulation of GTPase activity  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of phosphatidylinositol 3-kinase activity  mitochondrial fragmentation involved in apoptotic process  transcription regulatory region DNA binding  cell fate commitment  positive regulation of transcription, DNA-templated  protein autophosphorylation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cardiac muscle cell proliferation  mammary gland epithelial cell differentiation  mammary gland alveolus development  cardiac muscle tissue regeneration  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of STAT protein import into nucleus  negative regulation of neuron migration  
Pathways : BIOCARTAg-Secretase mediated ErbB4 Signaling [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGErbB signaling pathway    Calcium signaling pathway    Endocytosis    Proteoglycans in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkERBB4
Wikipedia pathwaysERBB4
Orthology - Evolution
OrthoDB2066
GeneTree (enSembl)ENSG00000178568
Phylogenetic Trees/Animal Genes : TreeFamERBB4
Homologs : HomoloGeneERBB4
Homology/Alignments : Family Browser (UCSC)ERBB4
Gene fusions - Rearrangements
Fusion: TCGAATAD2 8q24.13 ERBB4 2q34 HNSC
Fusion: TCGAATP2B4 1q32.1 ERBB4 2q34 LUAD
Fusion: TCGAC2orf67 ERBB4 2q34 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerERBB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERBB4
dbVarERBB4
ClinVarERBB4
1000_GenomesERBB4 
Exome Variant ServerERBB4
ExAC (Exome Aggregation Consortium)ERBB4 (select the gene name)
Genetic variants : HAPMAP2066
Genomic Variants (DGV)ERBB4 [DGVbeta]
Mutations
ICGC Data PortalERBB4 
TCGA Data PortalERBB4 
Broad Tumor PortalERBB4
OASIS PortalERBB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICERBB4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ERBB4
DgiDB (Drug Gene Interaction Database)ERBB4
DoCM (Curated mutations)ERBB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERBB4 (select a term)
intoGenERBB4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:212240442-213403352  ENSG00000178568
CONAN: Copy Number AnalysisERBB4 
Mutations and Diseases : HGMDERBB4
OMIM600543    615515   
MedgenERBB4
Genetic Testing Registry ERBB4
NextProtQ15303 [Medical]
TSGene2066
GENETestsERBB4
Huge Navigator ERBB4 [HugePedia]
snp3D : Map Gene to Disease2066
BioCentury BCIQERBB4
ClinGenERBB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2066
Chemical/Pharm GKB GenePA27847
Clinical trialERBB4
Miscellaneous
canSAR (ICR)ERBB4 (select the gene name)
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERBB4
EVEXERBB4
GoPubMedERBB4
iHOPERBB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:01:47 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.