ERF (ETS2 repressor factor)

2003-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CHYTS,CRS4,PE-2,PE2
FUSION GENES

Other Information

Locus ID:

NCBI: 2077
MIM: 611888
HGNC: 3444
Ensembl: ENSG00000105722

Variants:

dbSNP: 2077
ClinVar: 2077
TCGA: ENSG00000105722
COSMIC: ERF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105722ENST00000222329P50548
ENSG00000105722ENST00000222329A0A024R0L4
ENSG00000105722ENST00000440177P50548
ENSG00000105722ENST00000593944M0QXN0
ENSG00000105722ENST00000598965M0QX79

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221983862012EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.39
285150552017Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function <i>ERF</i> Mutations.24
286142982017ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.17
125336992003Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells.14
146118152003Role of Ets/Id proteins for telomerase regulation in human cancer cells.12
146787522003Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis.10
176991592007The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression.9
287506832017Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.9
175255312007Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.7
260970632015Heterozygous mutations in ERF cause syndromic craniosynostosis with multiple suture involvement.6

Citation

Dessen P

ERF (ETS2 repressor factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40485/erf