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ERVK-21 (endogenous retrovirus group K member 21, envelope)

Identity

Alias (NCBI)Endo-Rev2
PR
Protease
Proteinase
c12_A
envK1
HGNC (Hugo) ERVK-21
HGNC Alias symbc12_A
envK1
HGNC Alias nameHERV-K_12q14.1 provirus ancestral Env polyprotein
 HERV-K_12q14.1 provirus ancestral Gag polyprotein
 HERV-K_12q14.1 provirus ancestral Pro protein
 HERV-K_12q14.1 provirus Rec protein
HGNC Previous nameendogenous retrovirus group K, member 21
 endogenous retrovirus group K member 21
LocusID (NCBI) 100616103
Atlas_Id 56998
Location 12q14.1  [Link to chromosome band 12q14]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ERVK-21   39035
Cards
Entrez_Gene (NCBI)ERVK-21  100616103  endogenous retrovirus group K member 21, envelope
AliasesEndo-Rev2; PR; Protease; Proteinase; 
c12_A; envK1
GeneCards (Weizmann)ERVK-21
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  ERVK-21 [Vega]
TCGA cBioPortalERVK-21
AceView (NCBI)ERVK-21
Genatlas (Paris)ERVK-21
WikiGenes100616103
SOURCE (Princeton)ERVK-21
Genetics Home Reference (NIH)ERVK-21
Genomic and cartography
GoldenPath hg38 (UCSC)ERVK-21  -  
GoldenPath hg19 (UCSC)ERVK-21  -  
GoldenPathERVK-21 - [CytoView hg19]  ERVK-21 - [CytoView hg38]
genome Data Viewer NCBIERVK-21 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)FN806845
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ERVK-21
Gene ExpressionERVK-21 [ NCBI-GEO ]   ERVK-21 [ EBI - ARRAY_EXPRESS ]   ERVK-21 [ SEEK ]   ERVK-21 [ MEM ]
Gene Expression Viewer (FireBrowse)ERVK-21 [ Firebrowse - Broad ]
GenevisibleExpression of ERVK-21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100616103
GTEX Portal (Tissue expression)ERVK-21
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63119   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63119  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63119
Splice isoforms : SwissVarP63119
Catalytic activity : Enzyme3.4.23.50 [ Enzyme-Expasy ]   3.4.23.503.4.23.50 [ IntEnz-EBI ]   3.4.23.50 [ BRENDA ]   3.4.23.50 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP63119
Domaine pattern : Prosite (Expaxy)ASP_PROT_RETROV (PS50175)    ASP_PROTEASE (PS00141)    G_PATCH (PS50174)   
Domains : Interpro (EBI)Aspartic_peptidase_AS    G_patch_dom    Peptidase_A2_cat    Peptidase_aspartic_dom_sf    Retropepsin-like_cat_dom    Retropepsins   
Domain families : Pfam (Sanger)G-patch (PF01585)    RVP (PF00077)   
Domain families : Pfam (NCBI)pfam01585    pfam00077   
Domain families : Smart (EMBL)G_patch (SM00443)  
Conserved Domain (NCBI)ERVK-21
DMDM Disease mutations100616103
Blocks (Seattle)ERVK-21
SuperfamilyP63119
Peptide AtlasP63119
Protein Interaction databases
DIP (DOE-UCLA)P63119
IntAct (EBI)P63119
BioGRIDERVK-21
STRING (EMBL)ERVK-21
ZODIACERVK-21
Ontologies - Pathways
QuickGOP63119
Ontology : AmiGOsyncytium formation by plasma membrane fusion  molecular_function  structural molecule activity  cellular_component  plasma membrane  integral component of membrane  
Ontology : EGO-EBIsyncytium formation by plasma membrane fusion  molecular_function  structural molecule activity  cellular_component  plasma membrane  integral component of membrane  
NDEx NetworkERVK-21
Atlas of Cancer Signalling NetworkERVK-21
Wikipedia pathwaysERVK-21
Orthology - Evolution
OrthoDB100616103
Phylogenetic Trees/Animal Genes : TreeFamERVK-21
HOGENOMP63119
Homologs : HomoloGeneERVK-21
Homology/Alignments : Family Browser (UCSC)ERVK-21
Gene fusions - Rearrangements
Fusion : QuiverERVK-21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERVK-21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERVK-21
dbVarERVK-21
ClinVarERVK-21
MonarchERVK-21
1000_GenomesERVK-21 
Exome Variant ServerERVK-21
Varsome BrowserERVK-21
Genetic variants : HAPMAP100616103
Genomic Variants (DGV)ERVK-21 [DGVbeta]
DECIPHERERVK-21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERVK-21 
Mutations
ICGC Data PortalERVK-21 
TCGA Data PortalERVK-21 
Broad Tumor PortalERVK-21
OASIS PortalERVK-21 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDERVK-21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ERVK-21
DgiDB (Drug Gene Interaction Database)ERVK-21
DoCM (Curated mutations)ERVK-21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERVK-21 (select a term)
intoGenERVK-21
Cancer3DERVK-21(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETERVK-21
MedgenERVK-21
Genetic Testing Registry ERVK-21
NextProtP63119 [Medical]
TSGene100616103
GENETestsERVK-21
Target ValidationERVK-21
Huge Navigator ERVK-21 [HugePedia]
snp3D : Map Gene to Disease100616103
BioCentury BCIQERVK-21
ClinGenERVK-21
Clinical trials, drugs, therapy
Protein Interactions : CTD100616103
Clinical trialERVK-21
Miscellaneous
canSAR (ICR)ERVK-21 (select the gene name)
HarmonizomeERVK-21
DataMed IndexERVK-21
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERVK-21
EVEXERVK-21
GoPubMedERVK-21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:10:28 CEST 2020
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