ESRP2 (epithelial splicing regulatory protein 2)

2015-02-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
RBM35B
FUSION GENES

Other Information

Locus ID:

NCBI: 80004
MIM: 612960
HGNC: 26152
Ensembl: ENSG00000103067

Variants:

dbSNP: 80004
ClinVar: 80004
TCGA: ENSG00000103067
COSMIC: ESRP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103067ENST00000473183Q9H6T0
ENSG00000103067ENST00000562724J3KRF2
ENSG00000103067ENST00000564382J3QQJ9
ENSG00000103067ENST00000565858Q9H6T0
ENSG00000103067ENST00000566774J3QKU3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192859432009ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.234
207111672010An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition.157
198290822009The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.91
223549872012Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.75
251433902014Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.45
265310992015ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.32
265227222016The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.13
274010762017Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.11
279118562017Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.9
303228072018Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.2

Citation

Dessen P

ESRP2 (epithelial splicing regulatory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55032/esrp2