ETAA1 (ETAA1 activator of ATR kinase)

2007-02-01  

Identity

HGNC
ETAA1
LOCATION
2p14
LOCUSID
54465
ALIAS
ETAA16

Other Information

Locus ID:

NCBI: 54465
MIM: 613196
HGNC: 24648
Ensembl: ENSG00000143971

Variants:

dbSNP: 54465
ClinVar: 54465
TCGA: ENSG00000143971
COSMIC: ETAA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143971ENST00000272342Q9NY74
ENSG00000143971ENST00000462772A0A2R8Y6Y8
ENSG00000143971ENST00000644028A0A2R8Y7B6
ENSG00000143971ENST00000645739A0A2R8YEV8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277237202016ETAA1 acts at stalled replication forks to maintain genome integrity.63
277237172016Activation of the ATR kinase by the RPA-binding protein ETAA1.58
278181752016RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.34
276014672016Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks.20
160035592006Structure and function of ETAA16: a novel cell surface antigen in Ewing's tumours.8
307554692019Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1.8
309407282019Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation.2
316158752019Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.1

Citation

Dessen P

ETAA1 (ETAA1 activator of ATR kinase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45775/etaa1