ETF1 (eukaryotic translation termination factor 1)

2003-02-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
D5S1995,ERF,ERF1,RF1,SUP45L1,TB3-1
FUSION GENES

Other Information

Locus ID:

NCBI: 2107
MIM: 600285
HGNC: 3477
Ensembl: ENSG00000120705

Variants:

dbSNP: 2107
ClinVar: 2107
TCGA: ENSG00000120705
COSMIC: ETF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120705ENST00000360541P62495
ENSG00000120705ENST00000499810P62495
ENSG00000120705ENST00000503014B7Z7P8
ENSG00000120705ENST00000507939D6RJE8
ENSG00000120705ENST00000512198D6RCB3
ENSG00000120705ENST00000572514I3L492

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342723672021A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.41
342723672021A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.41
320597592020Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.38
320597592020Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.38
311166652019mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.12
311166652019mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.12
291272992017Origin of the omnipotence of eukaryotic release factor 1.4
291272992017Origin of the omnipotence of eukaryotic release factor 1.4
266552252016Chemical footprinting reveals conformational changes of 18S and 28S rRNAs at different steps of translation termination on the human ribosome.4
267259462016Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition.1
266552252016Chemical footprinting reveals conformational changes of 18S and 28S rRNAs at different steps of translation termination on the human ribosome.4
267259462016Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition.1
257357462015New insights into stop codon recognition by eRF1.18
262453812015Structural basis for stop codon recognition in eukaryotes.156
257357462015New insights into stop codon recognition by eRF1.18

Citation

Dessen P

ETF1 (eukaryotic translation termination factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40501/etf1