Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EVA1A (eva-1 homolog A, regulator of programmed cell death)

Identity

Alias_namesTMEM166
FAM176A
transmembrane protein 166
family with sequence similarity 176, member A
eva-1 homolog A (C. elegans)
Alias_symbol (synonym)FLJ13391
Other alias
HGNC (Hugo) EVA1A
LocusID (NCBI) 84141
Atlas_Id 53273
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 75492318 and ends at 75569722 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EVA1A (2p12) / TTC28 (22q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(2;22)(p12;q12) EVA1A/TTC28

External links

Nomenclature
HGNC (Hugo)EVA1A   25816
Cards
Entrez_Gene (NCBI)EVA1A  84141  eva-1 homolog A, regulator of programmed cell death
AliasesFAM176A; TMEM166
GeneCards (Weizmann)EVA1A
Ensembl hg19 (Hinxton)ENSG00000115363 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115363 [Gene_View]  ENSG00000115363 [Sequence]  chr2:75492318-75569722 [Contig_View]  EVA1A [Vega]
ICGC DataPortalENSG00000115363
TCGA cBioPortalEVA1A
AceView (NCBI)EVA1A
Genatlas (Paris)EVA1A
WikiGenes84141
SOURCE (Princeton)EVA1A
Genetics Home Reference (NIH)EVA1A
Genomic and cartography
GoldenPath hg38 (UCSC)EVA1A  -     chr2:75492318-75569722 -  2p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EVA1A  -     2p12   [Description]    (hg19-Feb_2009)
GoldenPathEVA1A - 2p12 [CytoView hg19]  EVA1A - 2p12 [CytoView hg38]
ImmunoBaseENSG00000115363
Mapping of homologs : NCBIEVA1A [Mapview hg19]  EVA1A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF177337 AK023453 AW016395 BC016157 BC063016
RefSeq transcript (Entrez)NM_001135032 NM_001369524 NM_001369525 NM_032181
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EVA1A
Cluster EST : UnigeneHs.302346 [ NCBI ]
CGAP (NCI)Hs.302346
Alternative Splicing GalleryENSG00000115363
Gene ExpressionEVA1A [ NCBI-GEO ]   EVA1A [ EBI - ARRAY_EXPRESS ]   EVA1A [ SEEK ]   EVA1A [ MEM ]
Gene Expression Viewer (FireBrowse)EVA1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84141
GTEX Portal (Tissue expression)EVA1A
Human Protein AtlasENSG00000115363-EVA1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H8M9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H8M9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H8M9
Splice isoforms : SwissVarQ9H8M9
PhosPhoSitePlusQ9H8M9
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)EVA1A
DMDM Disease mutations84141
Blocks (Seattle)EVA1A
SuperfamilyQ9H8M9
Human Protein Atlas [tissue]ENSG00000115363-EVA1A [tissue]
Peptide AtlasQ9H8M9
HPRD07827
IPIIPI00303867   IPI00916432   IPI00916738   IPI00916916   
Protein Interaction databases
DIP (DOE-UCLA)Q9H8M9
IntAct (EBI)Q9H8M9
FunCoupENSG00000115363
BioGRIDEVA1A
STRING (EMBL)EVA1A
ZODIACEVA1A
Ontologies - Pathways
QuickGOQ9H8M9
Ontology : AmiGOlysosomal membrane  endoplasmic reticulum lumen  endoplasmic reticulum membrane  plasma membrane  autophagy  apoptotic process  integral component of membrane  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  post-translational protein modification  cellular protein metabolic process  
Ontology : EGO-EBIlysosomal membrane  endoplasmic reticulum lumen  endoplasmic reticulum membrane  plasma membrane  autophagy  apoptotic process  integral component of membrane  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  post-translational protein modification  cellular protein metabolic process  
NDEx NetworkEVA1A
Atlas of Cancer Signalling NetworkEVA1A
Wikipedia pathwaysEVA1A
Orthology - Evolution
OrthoDB84141
GeneTree (enSembl)ENSG00000115363
Phylogenetic Trees/Animal Genes : TreeFamEVA1A
HOGENOMQ9H8M9
Homologs : HomoloGeneEVA1A
Homology/Alignments : Family Browser (UCSC)EVA1A
Gene fusions - Rearrangements
Fusion : MitelmanEVA1A/TTC28 [2p12/22q12.1]  
Fusion : QuiverEVA1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEVA1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EVA1A
dbVarEVA1A
ClinVarEVA1A
1000_GenomesEVA1A 
Exome Variant ServerEVA1A
ExAC (Exome Aggregation Consortium)ENSG00000115363
GNOMAD BrowserENSG00000115363
Varsome BrowserEVA1A
Genetic variants : HAPMAP84141
Genomic Variants (DGV)EVA1A [DGVbeta]
DECIPHEREVA1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEVA1A 
Mutations
ICGC Data PortalEVA1A 
TCGA Data PortalEVA1A 
Broad Tumor PortalEVA1A
OASIS PortalEVA1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEVA1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEVA1A
Mutations and Diseases : HGMDEVA1A
BioMutasearch EVA1A
DgiDB (Drug Gene Interaction Database)EVA1A
DoCM (Curated mutations)EVA1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EVA1A (select a term)
intoGenEVA1A
Cancer3DEVA1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETEVA1A
MedgenEVA1A
Genetic Testing Registry EVA1A
NextProtQ9H8M9 [Medical]
TSGene84141
GENETestsEVA1A
Target ValidationEVA1A
Huge Navigator EVA1A [HugePedia]
snp3D : Map Gene to Disease84141
BioCentury BCIQEVA1A
ClinGenEVA1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84141
Chemical/Pharm GKB GenePA162387354
Clinical trialEVA1A
Miscellaneous
canSAR (ICR)EVA1A (select the gene name)
DataMed IndexEVA1A
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEVA1A
EVEXEVA1A
GoPubMedEVA1A
iHOPEVA1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:42:26 CET 2019
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