Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EXD2 (exonuclease 3'-5' domain containing 2)

Identity

Alias (NCBI)C14orf114
EXDL2
HGNC (Hugo) EXD2
HGNC Alias symbFLJ10738
HGNC Previous nameC14orf114
 EXDL2
HGNC Previous namechromosome 14 open reading frame 114
 exonuclease 3'-5' domain-like 2
LocusID (NCBI) 55218
Atlas_Id 55696
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 69191477 and ends at 69244020 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EXD2 (14q24.1) / EXD2 (14q24.1)EXD2 (14q24.1) / FAM162A (3q21.1)EXD2 (14q24.1) / GMEB2 (20q13.33)
HS3ST1 (4p15.33) / EXD2 (14q24.1)PTPRT (20q12) / EXD2 (14q24.1)SLIRP (14q24.3) / EXD2 (14q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;20)(q24;q13) EXD2/GMEB2
t(14;20)(q24;q13) PTPRT/EXD2


External links

Nomenclature
HGNC (Hugo)EXD2   20217
Cards
Entrez_Gene (NCBI)EXD2  55218  exonuclease 3'-5' domain containing 2
AliasesC14orf114; EXDL2
GeneCards (Weizmann)EXD2
Ensembl hg19 (Hinxton)ENSG00000081177 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081177 [Gene_View]  ENSG00000081177 [Sequence]  chr14:69191477-69244020 [Contig_View]  EXD2 [Vega]
ICGC DataPortalENSG00000081177
TCGA cBioPortalEXD2
AceView (NCBI)EXD2
Genatlas (Paris)EXD2
WikiGenes55218
SOURCE (Princeton)EXD2
Genetics Home Reference (NIH)EXD2
Genomic and cartography
GoldenPath hg38 (UCSC)EXD2  -     chr14:69191477-69244020 +  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXD2  -     14q24.1   [Description]    (hg19-Feb_2009)
GoldenPathEXD2 - 14q24.1 [CytoView hg19]  EXD2 - 14q24.1 [CytoView hg38]
ImmunoBaseENSG00000081177
genome Data Viewer NCBIEXD2 [Mapview hg19]  
OMIM616940   
Gene and transcription
Genbank (Entrez)AK001600 AK056025 AK292563 AK295601 AL834434
RefSeq transcript (Entrez)NM_001193360 NM_001193361 NM_001193362 NM_001193363 NM_018199
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXD2
Alternative Splicing GalleryENSG00000081177
Gene ExpressionEXD2 [ NCBI-GEO ]   EXD2 [ EBI - ARRAY_EXPRESS ]   EXD2 [ SEEK ]   EXD2 [ MEM ]
Gene Expression Viewer (FireBrowse)EXD2 [ Firebrowse - Broad ]
GenevisibleExpression of EXD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55218
GTEX Portal (Tissue expression)EXD2
Human Protein AtlasENSG00000081177-EXD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVH0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVH0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVH0
Splice isoforms : SwissVarQ9NVH0
PhosPhoSitePlusQ9NVH0
Domains : Interpro (EBI)3'-5'_exonuclease_dom    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)DNA_pol_A_exo1 (PF01612)   
Domain families : Pfam (NCBI)pfam01612   
Domain families : Smart (EMBL)35EXOc (SM00474)  
Conserved Domain (NCBI)EXD2
DMDM Disease mutations55218
Blocks (Seattle)EXD2
PDB (RSDB)6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
PDB Europe6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
PDB (PDBSum)6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
PDB (IMB)6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
Structural Biology KnowledgeBase6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
SCOP (Structural Classification of Proteins)6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
CATH (Classification of proteins structures)6K17    6K18    6K19    6K1A    6K1B    6K1C    6K1D    6K1E   
SuperfamilyQ9NVH0
Human Protein Atlas [tissue]ENSG00000081177-EXD2 [tissue]
Peptide AtlasQ9NVH0
HPRD16592
IPIIPI00915852   IPI00916247   IPI00384169   IPI00465113   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVH0
IntAct (EBI)Q9NVH0
FunCoupENSG00000081177
BioGRIDEXD2
STRING (EMBL)EXD2
ZODIACEXD2
Ontologies - Pathways
QuickGOQ9NVH0
Ontology : AmiGO3'-5'-exoribonuclease activity  magnesium ion binding  double-strand break repair via homologous recombination  DNA double-strand break processing  nucleic acid binding  protein binding  nucleus  cytoplasm  mitochondrial outer membrane  mitochondrial matrix  double-strand break repair  3'-5'-exodeoxyribonuclease activity  single-stranded DNA 3'-5' exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease I activity  integral component of membrane  manganese ion binding  replication fork processing  protein homodimerization activity  nucleic acid phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, exonucleolytic  site of DNA damage  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  magnesium ion binding  double-strand break repair via homologous recombination  DNA double-strand break processing  nucleic acid binding  protein binding  nucleus  cytoplasm  mitochondrial outer membrane  mitochondrial matrix  double-strand break repair  3'-5'-exodeoxyribonuclease activity  single-stranded DNA 3'-5' exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease I activity  integral component of membrane  manganese ion binding  replication fork processing  protein homodimerization activity  nucleic acid phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, exonucleolytic  site of DNA damage  
NDEx NetworkEXD2
Atlas of Cancer Signalling NetworkEXD2
Wikipedia pathwaysEXD2
Orthology - Evolution
OrthoDB55218
GeneTree (enSembl)ENSG00000081177
Phylogenetic Trees/Animal Genes : TreeFamEXD2
HOGENOMQ9NVH0
Homologs : HomoloGeneEXD2
Homology/Alignments : Family Browser (UCSC)EXD2
Gene fusions - Rearrangements
Fusion : QuiverEXD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXD2
dbVarEXD2
ClinVarEXD2
1000_GenomesEXD2 
Exome Variant ServerEXD2
GNOMAD BrowserENSG00000081177
Varsome BrowserEXD2
Genetic variants : HAPMAP55218
Genomic Variants (DGV)EXD2 [DGVbeta]
DECIPHEREXD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXD2 
Mutations
ICGC Data PortalEXD2 
TCGA Data PortalEXD2 
Broad Tumor PortalEXD2
OASIS PortalEXD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXD2
Mutations and Diseases : HGMDEXD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXD2
DgiDB (Drug Gene Interaction Database)EXD2
DoCM (Curated mutations)EXD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXD2 (select a term)
intoGenEXD2
Cancer3DEXD2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616940   
Orphanet
DisGeNETEXD2
MedgenEXD2
Genetic Testing Registry EXD2
NextProtQ9NVH0 [Medical]
TSGene55218
GENETestsEXD2
Target ValidationEXD2
Huge Navigator EXD2 [HugePedia]
snp3D : Map Gene to Disease55218
BioCentury BCIQEXD2
ClinGenEXD2
Clinical trials, drugs, therapy
Protein Interactions : CTD55218
Pharm GKB GenePA164719421
Clinical trialEXD2
Miscellaneous
canSAR (ICR)EXD2 (select the gene name)
HarmonizomeEXD2
DataMed IndexEXD2
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXD2
EVEXEXD2
GoPubMedEXD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:12:34 CEST 2020

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