EXOC3 (exocyst complex component 3)

2003-12-01  

Identity

HGNC
EXOC3
LOCATION
5p15.33
LOCUSID
11336
ALIAS
SEC6,SEC6L1,Sec6p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11336
MIM: 608186
HGNC: 30378
Ensembl: ENSG00000180104

Variants:

dbSNP: 11336
ClinVar: 11336
TCGA: ENSG00000180104
COSMIC: EXOC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180104ENST00000315013O60645
ENSG00000180104ENST00000315013A0A024QYZ6
ENSG00000180104ENST00000503889H0Y995
ENSG00000180104ENST00000508022D6RBR9
ENSG00000180104ENST00000512944O60645
ENSG00000180104ENST00000512944A0A024QYZ6
ENSG00000180104ENST00000515601D6RB59

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

References

Pubmed IDYearTitleCitations
262837292015Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.4
223813372012Knockdown of Sec6 improves cell-cell adhesion by increasing α-E-catenin in oral cancer cells.3
249498322014Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1.2
262479212016Nuclear Translocation of p65 is Controlled by Sec6 via the Degradation of IκBα.2
268920092016Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.1
297293352018Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.1

Citation

Dessen P

EXOC3 (exocyst complex component 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42243/exoc3