Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EXOC5 (exocyst complex component 5)

Identity

Alias_namesSEC10L1
SEC10 (S. cerevisiae)-like 1
SEC10-like 1 (S. cerevisiae)
Alias_symbol (synonym)SEC10
SEC10P
Other aliasHSEC10
PRO1912
HGNC (Hugo) EXOC5
LocusID (NCBI) 10640
Atlas_Id 55272
Location 14q22.3  [Link to chromosome band 14q22]
Location_base_pair Starts at 57202476 and ends at 57268899 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EXOC5 (14q22.3) / EXOC5 (14q22.3)EXOC5 (14q22.3) / SLC35F4 (14q22.3)EXOC5 14q22.3 / SLC35F4 14q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;14)(q22;q23) EXOC5/SLC35F4

External links

Nomenclature
HGNC (Hugo)EXOC5   10696
Cards
Entrez_Gene (NCBI)EXOC5  10640  exocyst complex component 5
AliasesHSEC10; PRO1912; SEC10; SEC10L1; 
SEC10P
GeneCards (Weizmann)EXOC5
Ensembl hg19 (Hinxton)ENSG00000070367 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070367 [Gene_View]  ENSG00000070367 [Sequence]  chr14:57202476-57268899 [Contig_View]  EXOC5 [Vega]
ICGC DataPortalENSG00000070367
TCGA cBioPortalEXOC5
AceView (NCBI)EXOC5
Genatlas (Paris)EXOC5
WikiGenes10640
SOURCE (Princeton)EXOC5
Genetics Home Reference (NIH)EXOC5
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC5  -     chr14:57202476-57268899 -  14q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC5  -     14q22.3   [Description]    (hg19-Feb_2009)
GoldenPathEXOC5 - 14q22.3 [CytoView hg19]  EXOC5 - 14q22.3 [CytoView hg38]
ImmunoBaseENSG00000070367
Mapping of homologs : NCBIEXOC5 [Mapview hg19]  EXOC5 [Mapview hg38]
OMIM604469   
Gene and transcription
Genbank (Entrez)AA837306 AF118083 AK025802 AK295085 AK303531
RefSeq transcript (Entrez)NM_006544
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOC5
Cluster EST : UnigeneHs.743987 [ NCBI ]
CGAP (NCI)Hs.743987
Alternative Splicing GalleryENSG00000070367
Gene ExpressionEXOC5 [ NCBI-GEO ]   EXOC5 [ EBI - ARRAY_EXPRESS ]   EXOC5 [ SEEK ]   EXOC5 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10640
GTEX Portal (Tissue expression)EXOC5
Human Protein AtlasENSG00000070367-EXOC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00471
Splice isoforms : SwissVarO00471
PhosPhoSitePlusO00471
Domains : Interpro (EBI)EXOC5/Sec10    Sec10-like   
Domain families : Pfam (Sanger)Sec10 (PF07393)   
Domain families : Pfam (NCBI)pfam07393   
Conserved Domain (NCBI)EXOC5
DMDM Disease mutations10640
Blocks (Seattle)EXOC5
SuperfamilyO00471
Human Protein Atlas [tissue]ENSG00000070367-EXOC5 [tissue]
Peptide AtlasO00471
HPRD07258
IPIIPI00719051   IPI00829808   IPI00016881   IPI01026446   IPI01026563   
Protein Interaction databases
DIP (DOE-UCLA)O00471
IntAct (EBI)O00471
FunCoupENSG00000070367
BioGRIDEXOC5
STRING (EMBL)EXOC5
ZODIACEXOC5
Ontologies - Pathways
QuickGOO00471
Ontology : AmiGOexocyst  establishment of planar polarity  protein binding  cytoplasm  cytosol  exocytosis  post-Golgi vesicle-mediated transport  Golgi to plasma membrane transport  protein transport  Ral GTPase binding  midbody  protein N-terminus binding  vesicle docking  protein localization to plasma membrane  epithelial cell apoptotic process  non-motile cilium assembly  
Ontology : EGO-EBIexocyst  establishment of planar polarity  protein binding  cytoplasm  cytosol  exocytosis  post-Golgi vesicle-mediated transport  Golgi to plasma membrane transport  protein transport  Ral GTPase binding  midbody  protein N-terminus binding  vesicle docking  protein localization to plasma membrane  epithelial cell apoptotic process  non-motile cilium assembly  
NDEx NetworkEXOC5
Atlas of Cancer Signalling NetworkEXOC5
Wikipedia pathwaysEXOC5
Orthology - Evolution
OrthoDB10640
GeneTree (enSembl)ENSG00000070367
Phylogenetic Trees/Animal Genes : TreeFamEXOC5
HOGENOMO00471
Homologs : HomoloGeneEXOC5
Homology/Alignments : Family Browser (UCSC)EXOC5
Gene fusions - Rearrangements
Fusion : MitelmanEXOC5/SLC35F4 [14q22.3/14q22.3]  
Fusion PortalEXOC5 14q22.3 SLC35F4 14q22.3 PRAD
Fusion : QuiverEXOC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC5
dbVarEXOC5
ClinVarEXOC5
1000_GenomesEXOC5 
Exome Variant ServerEXOC5
ExAC (Exome Aggregation Consortium)ENSG00000070367
GNOMAD BrowserENSG00000070367
Varsome BrowserEXOC5
Genetic variants : HAPMAP10640
Genomic Variants (DGV)EXOC5 [DGVbeta]
DECIPHEREXOC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC5 
Mutations
ICGC Data PortalEXOC5 
TCGA Data PortalEXOC5 
Broad Tumor PortalEXOC5
OASIS PortalEXOC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXOC5
Mutations and Diseases : HGMDEXOC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOC5
DgiDB (Drug Gene Interaction Database)EXOC5
DoCM (Curated mutations)EXOC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOC5 (select a term)
intoGenEXOC5
Cancer3DEXOC5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604469   
Orphanet
DisGeNETEXOC5
MedgenEXOC5
Genetic Testing Registry EXOC5
NextProtO00471 [Medical]
TSGene10640
GENETestsEXOC5
Target ValidationEXOC5
Huge Navigator EXOC5 [HugePedia]
snp3D : Map Gene to Disease10640
BioCentury BCIQEXOC5
ClinGenEXOC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10640
Chemical/Pharm GKB GenePA35619
Clinical trialEXOC5
Miscellaneous
canSAR (ICR)EXOC5 (select the gene name)
DataMed IndexEXOC5
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOC5
EVEXEXOC5
GoPubMedEXOC5
iHOPEXOC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:42:31 CET 2019
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