Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EXOG (exo/endonuclease G)

Identity

Alias_namesENDOGL1
ENDOGL2
endonuclease G-like 1
endonuclease G-like 2
endo/exonuclease (5'-3'), endonuclease G-like
Alias_symbol (synonym)ENGL-a
ENGL
ENGL-b
Other aliasENGLA
ENGLB
HGNC (Hugo) EXOG
LocusID (NCBI) 9941
Atlas_Id 57775
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 38496272 and ends at 38526305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EXOG   3347
Cards
Entrez_Gene (NCBI)EXOG  9941  exo/endonuclease G
AliasesENDOGL1; ENDOGL2; ENGL; ENGL-a; 
ENGL-b; ENGLA; ENGLB
GeneCards (Weizmann)EXOG
Ensembl hg19 (Hinxton)ENSG00000157036 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157036 [Gene_View]  ENSG00000157036 [Sequence]  chr3:38496272-38526305 [Contig_View]  EXOG [Vega]
ICGC DataPortalENSG00000157036
TCGA cBioPortalEXOG
AceView (NCBI)EXOG
Genatlas (Paris)EXOG
WikiGenes9941
SOURCE (Princeton)EXOG
Genetics Home Reference (NIH)EXOG
Genomic and cartography
GoldenPath hg38 (UCSC)EXOG  -     chr3:38496272-38526305 +  3p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOG  -     3p22.2   [Description]    (hg19-Feb_2009)
GoldenPathEXOG - 3p22.2 [CytoView hg19]  EXOG - 3p22.2 [CytoView hg38]
ImmunoBaseENSG00000157036
Mapping of homologs : NCBIEXOG [Mapview hg19]  EXOG [Mapview hg38]
OMIM604051   
Gene and transcription
Genbank (Entrez)AA993872 AB020523 AK023235 AK289602 AK290107
RefSeq transcript (Entrez)NM_001145464 NM_001318954 NM_001318955 NM_001318956 NM_001318957 NM_001318958 NM_001318959 NM_005107
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOG
Cluster EST : UnigeneHs.517897 [ NCBI ]
CGAP (NCI)Hs.517897
Alternative Splicing GalleryENSG00000157036
Gene ExpressionEXOG [ NCBI-GEO ]   EXOG [ EBI - ARRAY_EXPRESS ]   EXOG [ SEEK ]   EXOG [ MEM ]
Gene Expression Viewer (FireBrowse)EXOG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9941
GTEX Portal (Tissue expression)EXOG
Human Protein AtlasENSG00000157036-EXOG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2C4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2C4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2C4
Splice isoforms : SwissVarQ9Y2C4
Catalytic activity : Enzyme3.1.30.- [ Enzyme-Expasy ]   3.1.30.-3.1.30.- [ IntEnz-EBI ]   3.1.30.- [ BRENDA ]   3.1.30.- [ KEGG ]   
PhosPhoSitePlusQ9Y2C4
Domains : Interpro (EBI)DNA/RNA_non-sp_Endonuclease    Extracellular_endonuc_su_A   
Domain families : Pfam (Sanger)Endonuclease_NS (PF01223)   
Domain families : Pfam (NCBI)pfam01223   
Domain families : Smart (EMBL)Endonuclease_NS (SM00892)  NUC (SM00477)  
Conserved Domain (NCBI)EXOG
DMDM Disease mutations9941
Blocks (Seattle)EXOG
PDB (RSDB)4A1N    5T3V    5T40    5T4I    5T5C   
PDB Europe4A1N    5T3V    5T40    5T4I    5T5C   
PDB (PDBSum)4A1N    5T3V    5T40    5T4I    5T5C   
PDB (IMB)4A1N    5T3V    5T40    5T4I    5T5C   
Structural Biology KnowledgeBase4A1N    5T3V    5T40    5T4I    5T5C   
SCOP (Structural Classification of Proteins)4A1N    5T3V    5T40    5T4I    5T5C   
CATH (Classification of proteins structures)4A1N    5T3V    5T40    5T4I    5T5C   
SuperfamilyQ9Y2C4
Human Protein Atlas [tissue]ENSG00000157036-EXOG [tissue]
Peptide AtlasQ9Y2C4
IPIIPI00021106   IPI00024713   IPI00926574   IPI01018335   IPI00925877   IPI00927725   IPI00927506   IPI00925148   IPI00927095   IPI00925648   IPI00925869   IPI00965953   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2C4
IntAct (EBI)Q9Y2C4
FunCoupENSG00000157036
BioGRIDEXOG
STRING (EMBL)EXOG
ZODIACEXOG
Ontologies - Pathways
QuickGOQ9Y2C4
Ontology : AmiGOsingle-stranded DNA endodeoxyribonuclease activity  DNA catabolic process, endonucleolytic  nucleic acid binding  endonuclease activity  endonuclease activity  endonuclease activity  endoribonuclease activity  exodeoxyribonuclease activity  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  apoptotic DNA fragmentation  biological_process  5'-3' exonuclease activity  5'-3' exonuclease activity  protein-containing complex  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBIsingle-stranded DNA endodeoxyribonuclease activity  DNA catabolic process, endonucleolytic  nucleic acid binding  endonuclease activity  endonuclease activity  endonuclease activity  endoribonuclease activity  exodeoxyribonuclease activity  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  apoptotic DNA fragmentation  biological_process  5'-3' exonuclease activity  5'-3' exonuclease activity  protein-containing complex  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkEXOG
Atlas of Cancer Signalling NetworkEXOG
Wikipedia pathwaysEXOG
Orthology - Evolution
OrthoDB9941
GeneTree (enSembl)ENSG00000157036
Phylogenetic Trees/Animal Genes : TreeFamEXOG
HOGENOMQ9Y2C4
Homologs : HomoloGeneEXOG
Homology/Alignments : Family Browser (UCSC)EXOG
Gene fusions - Rearrangements
Fusion : QuiverEXOG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOG
dbVarEXOG
ClinVarEXOG
1000_GenomesEXOG 
Exome Variant ServerEXOG
ExAC (Exome Aggregation Consortium)ENSG00000157036
GNOMAD BrowserENSG00000157036
Varsome BrowserEXOG
Genetic variants : HAPMAP9941
Genomic Variants (DGV)EXOG [DGVbeta]
DECIPHEREXOG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOG 
Mutations
ICGC Data PortalEXOG 
TCGA Data PortalEXOG 
Broad Tumor PortalEXOG
OASIS PortalEXOG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXOG
Mutations and Diseases : HGMDEXOG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOG
DgiDB (Drug Gene Interaction Database)EXOG
DoCM (Curated mutations)EXOG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOG (select a term)
intoGenEXOG
Cancer3DEXOG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604051   
Orphanet
DisGeNETEXOG
MedgenEXOG
Genetic Testing Registry EXOG
NextProtQ9Y2C4 [Medical]
TSGene9941
GENETestsEXOG
Target ValidationEXOG
Huge Navigator EXOG [HugePedia]
snp3D : Map Gene to Disease9941
BioCentury BCIQEXOG
ClinGenEXOG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9941
Chemical/Pharm GKB GenePA27784
Clinical trialEXOG
Miscellaneous
canSAR (ICR)EXOG (select the gene name)
DataMed IndexEXOG
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOG
EVEXEXOG
GoPubMedEXOG
iHOPEXOG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:42:32 CET 2019
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