EXOSC5 (exosome component 5)

2008-09-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
RRP41B,RRP46,Rrp46p,hRrp46p,p12B
FUSION GENES

Other Information

Locus ID:

NCBI: 56915
MIM: 606492
HGNC: 24662
Ensembl: ENSG00000077348

Variants:

dbSNP: 56915
ClinVar: 56915
TCGA: ENSG00000077348
COSMIC: EXOSC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077348ENST00000221233Q9NQT4
ENSG00000077348ENST00000593771M0R102
ENSG00000077348ENST00000596905M0R050
ENSG00000077348ENST00000602129M0R289

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Exosome, eukaryotesKEGGhsa_M00391
Exosome, eukaryotesKEGGM00391
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 3' to 5' exoribonucleaseREACTOMER-HSA-429958
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAREACTOMER-HSA-450385
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124192562002Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.25
118121492002Protein-protein interactions of hCsl4p with other human exosome subunits.10
181574972008Activation of cytotoxic T lymphocytes against CML28-bearing tumors by dendritic cells transduced with a recombinant adeno-associated virus encoding the CML28 gene.6
168153012006Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector.4
206600802010Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation.4
305679892019Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA.2
233927052013Interaction of human genes WT1 and CML28 in leukemic cells.0

Citation

Dessen P

EXOSC5 (exosome component 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50386/exosc5