| Nomenclature |
|---|
| HGNC (Hugo) | EXOSC6 19055 |
| Cards |
|---|
| Entrez_Gene (NCBI) | EXOSC6 118460 exosome component 6 |
| Aliases | EAP4; MTR3; Mtr3p; hMtr3p; |
| p11 |
| GeneCards (Weizmann) | EXOSC6 |
| Ensembl hg19 (Hinxton) | ENSG00000223496 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000223496 [Gene_View] ENSG00000223496 [Sequence] chr16:70250231-70251930 [Contig_View] EXOSC6 [Vega] |
| ICGC DataPortal | ENSG00000223496 |
| TCGA cBioPortal | EXOSC6 |
| AceView (NCBI) | EXOSC6 |
| Genatlas (Paris) | EXOSC6 |
| WikiGenes | 118460 |
| SOURCE (Princeton) | EXOSC6 |
| Genetics Home Reference (NIH) | EXOSC6 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | EXOSC6 - chr16:70250231-70251930 - 16q22.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | EXOSC6 - 16q22.1 [Description] (hg19-Feb_2009) |
| GoldenPath | EXOSC6 - 16q22.1 [CytoView hg19] EXOSC6 - 16q22.1 [CytoView hg38] |
| ImmunoBase | ENSG00000223496 |
| Mapping of homologs : NCBI | EXOSC6 [Mapview hg19] EXOSC6 [Mapview hg38] |
| OMIM | 606490 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK024276 AK095542 BC052252 CX866575 |
| RefSeq transcript (Entrez) | NM_058219 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | EXOSC6 |
| Cluster EST : Unigene | Hs.744085 [ NCBI ] |
| CGAP (NCI) | Hs.744085 |
| Alternative Splicing Gallery | ENSG00000223496 |
| Gene Expression | EXOSC6 [ NCBI-GEO ] EXOSC6 [ EBI - ARRAY_EXPRESS ]
EXOSC6 [ SEEK ] EXOSC6 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | EXOSC6 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 118460 |
| GTEX Portal (Tissue expression) | EXOSC6 |
| Human Protein Atlas | ENSG00000223496-EXOSC6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q5RKV6 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q5RKV6 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q5RKV6 |
| Splice isoforms : SwissVar | Q5RKV6 |
| PhosPhoSitePlus | Q5RKV6 |
| Domains : Interpro (EBI) | ExoRNase_PH_dom1 ExoRNase_PH_dom2_sf PNPase/RNase_PH_dom_sf Ribosomal_S5_D2-typ_fold |
| Domain families : Pfam (Sanger) | RNase_PH (PF01138) |
| Domain families : Pfam (NCBI) | pfam01138 |
| Conserved Domain (NCBI) | EXOSC6 |
| DMDM Disease mutations | 118460 |
| Blocks (Seattle) | EXOSC6 |
| PDB (RSDB) | 2NN6 |
| PDB Europe | 2NN6 |
| PDB (PDBSum) | 2NN6 |
| PDB (IMB) | 2NN6 |
| Structural Biology KnowledgeBase | 2NN6 |
| SCOP (Structural Classification of Proteins) | 2NN6 |
| CATH (Classification of proteins structures) | 2NN6 |
| Superfamily | Q5RKV6 |
| Human Protein Atlas [tissue] | ENSG00000223496-EXOSC6 [tissue] |
| Peptide Atlas | Q5RKV6 |
| HPRD | 12107 |
| IPI | IPI00073602 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q5RKV6 |
| IntAct (EBI) | Q5RKV6 |
| FunCoup | ENSG00000223496 |
| BioGRID | EXOSC6 |
| STRING (EMBL) | EXOSC6 |
| ZODIAC | EXOSC6 |
| Ontologies - Pathways |
|---|
| QuickGO | Q5RKV6 |
| Ontology : AmiGO | nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding exoribonuclease activity nucleoplasm nucleolus cytosol rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination isotype switching positive regulation of isotype switching nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing RNA phosphodiester bond hydrolysis, exonucleolytic |
| Ontology : EGO-EBI | nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding exoribonuclease activity nucleoplasm nucleolus cytosol rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination isotype switching positive regulation of isotype switching nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing RNA phosphodiester bond hydrolysis, exonucleolytic |
| NDEx Network | EXOSC6 |
| Atlas of Cancer Signalling Network | EXOSC6 |
| Wikipedia pathways | EXOSC6 |
| Orthology - Evolution |
|---|
| OrthoDB | 118460 |
| GeneTree (enSembl) | ENSG00000223496 |
| Phylogenetic Trees/Animal Genes : TreeFam | EXOSC6 |
| HOGENOM | Q5RKV6 |
| Homologs : HomoloGene | EXOSC6 |
| Homology/Alignments : Family Browser (UCSC) | EXOSC6 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | EXOSC6 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | EXOSC6 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | EXOSC6 |
| dbVar | EXOSC6 |
| ClinVar | EXOSC6 |
| 1000_Genomes | EXOSC6 |
| Exome Variant Server | EXOSC6 |
| ExAC (Exome Aggregation Consortium) | ENSG00000223496 |
| GNOMAD Browser | ENSG00000223496 |
| Varsome Browser | EXOSC6 |
| Genetic variants : HAPMAP | 118460 |
| Genomic Variants (DGV) | EXOSC6 [DGVbeta] |
| DECIPHER | EXOSC6 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | EXOSC6 |
| Mutations |
|---|
| ICGC Data Portal | EXOSC6 |
| TCGA Data Portal | EXOSC6 |
| Broad Tumor Portal | EXOSC6 |
| OASIS Portal | EXOSC6 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | EXOSC6 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | EXOSC6 |
| Mutations and Diseases : HGMD | EXOSC6 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search EXOSC6 |
| DgiDB (Drug Gene Interaction Database) | EXOSC6 |
| DoCM (Curated mutations) | EXOSC6 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | EXOSC6 (select a term) |
| intoGen | EXOSC6 |
| Cancer3D | EXOSC6(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 606490 |
| Orphanet | |
| DisGeNET | EXOSC6 |
| Medgen | EXOSC6 |
| Genetic Testing Registry | EXOSC6
|
| NextProt | Q5RKV6 [Medical] |
| TSGene | 118460 |
| GENETests | EXOSC6 |
| Target Validation | EXOSC6 |
| Huge Navigator |
EXOSC6 [HugePedia] |
| snp3D : Map Gene to Disease | 118460 |
| BioCentury BCIQ | EXOSC6 |
| ClinGen | EXOSC6 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 118460 |
| Chemical/Pharm GKB Gene | PA134932096 |
| Clinical trial | EXOSC6 |
| Miscellaneous |
|---|
| canSAR (ICR) | EXOSC6 (select the gene name) |
| DataMed Index | EXOSC6 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 43 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | EXOSC6 |
| EVEX | EXOSC6 |
| GoPubMed | EXOSC6 |
| iHOP | EXOSC6 |
