F10 (coagulation factor X)

2007-02-01  

Identity

HGNC
LOCATION
13q34
LOCUSID
ALIAS
FX,FXA
FUSION GENES

Other Information

Locus ID:

NCBI: 2159
MIM: 613872
HGNC: 3528
Ensembl: ENSG00000126218

Variants:

dbSNP: 2159
ClinVar: 2159
TCGA: ENSG00000126218
COSMIC: F10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126218ENST00000375551Q5JVE8
ENSG00000126218ENST00000375559P00742
ENSG00000126218ENST00000375559Q5JVE7
ENSG00000126218ENST00000409306B7ZBK1
ENSG00000126218ENST00000410083F8WBM7

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsREACTOMER-HSA-159854
Gamma-carboxylation of protein precursorsREACTOMER-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusREACTOMER-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteinsREACTOMER-HSA-159782
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA28660GGCXGenePathwayassociated

References

Pubmed IDYearTitleCitations
182670722008Adenovirus serotype 5 hexon mediates liver gene transfer.271
183912092008Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo.153
196523652009Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
194298662009Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.79
201350592010Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor.79
165808982006Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.74
206942732010Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation.59
230196122012Coagulation factor X activates innate immunity to human species C adenovirus.59
209787142010Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.58

Citation

Dessen P

F10 (coagulation factor X)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46152/f10