F11 (coagulation factor XI)

2003-05-01 Affiliation

Identity

HGNC

F11

LOCATION

4q35.2

LOCUSID

2160

ALIAS

FXI,PTA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2160
MIM: 264900
HGNC: 3529
Ensembl: ENSG00000088926

Variants:

dbSNP: 2160
ClinVar: 2160
TCGA: ENSG00000088926
COSMIC: F11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000088926	ENST00000264691	X6R3B1
ENSG00000088926	ENST00000264692	P03951
ENSG00000088926	ENST00000403665	P03951
ENSG00000088926	ENST00000452239	H0Y596
ENSG00000088926	ENST00000492972	D6RB32

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Hemostasis	REACTOME	R-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA452637	hormonal contraceptives for systemic use	Chemical	ClinicalAnnotation	associated		PD	28750087

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17284699	2007	Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.	58
18268095	2008	Reduced incidence of ischemic stroke in patients with severe factor XI deficiency.	57
20110423	2010	Structure and function of factor XI.	54
19351955	2009	Factor XI contributes to thrombin generation in the absence of factor XII.	51
21057700	2011	Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis.	39
19617576	2009	Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology.	33
18217146	2008	Factor XIa and tissue factor activity in patients with coronary artery disease.	32
26136249	2015	FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow.	32
21527525	2011	Activation of factor XI by products of prothrombin activation.	29

Citation

Dessen P

F11 (coagulation factor XI)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40519/f11