F13A1 (coagulation factor XIII A chain)

2007-06-01  

Identity

HGNC
LOCATION
6p25.1
LOCUSID
ALIAS
F13A
FUSION GENES

Other Information

Locus ID:

NCBI: 2162
MIM: 134570
HGNC: 3531
Ensembl: ENSG00000124491

Variants:

dbSNP: 2162
ClinVar: 2162
TCGA: ENSG00000124491
COSMIC: F13A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124491ENST00000264870P00488
ENSG00000124491ENST00000414279Q9NQP5
ENSG00000124491ENST00000431222A6PVK5
ENSG00000124491ENST00000445223H0Y4W5
ENSG00000124491ENST00000451619H0Y796

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165984462photodynamic therapyChemicalClinicalAnnotationassociatedPD
PA443450AsthmaDiseaseLiterature, MultilinkAnnotationassociated24934276
PA446974Choroidal NeovascularizationDiseaseClinicalAnnotationassociatedPD
PA448497aspirinChemicalClinicalAnnotationassociatedPD12515735
PA451906warfarinChemicalVariantAnnotationnot associated

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155341752004Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.78
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197832162009Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study.45
263247042015Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking.39
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.34
211315892011Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.34
189748422008Gender differences in genetic risk profiles for cardiovascular disease.33

Citation

Dessen P

F13A1 (coagulation factor XIII A chain)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47551/f13a1