FABP1 (fatty acid binding protein 1)

2009-05-01  

Identity

HGNC
FABP1
LOCATION
2p11.2
LOCUSID
2168
ALIAS
FABPL,L-FABP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2168
MIM: 134650
HGNC: 3555
Ensembl: ENSG00000163586

Variants:

dbSNP: 2168
ClinVar: 2168
TCGA: ENSG00000163586
COSMIC: FABP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163586ENST00000295834P07148
ENSG00000163586ENST00000295834Q6FGL7
ENSG00000163586ENST00000393750A8MW49

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446120HypertriglyceridemiaDiseaseClinicalAnnotationassociatedPD15249972
PA449594fenofibrateChemicalClinicalAnnotationassociatedPD15249972

References

Pubmed IDYearTitleCitations
180946802008Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
145634462003Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility.84
235994082013Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery.75
243755762014Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury.51
193308632009Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease.48
161756092005Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells.44
201857322010Urinary liver-type fatty acid-binding protein predicts progression to nephropathy in type 1 diabetic patients.32
190199182009Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury.30
232233502013Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy.30

Citation

Dessen P

FABP1 (fatty acid binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50906/fabp1