FAM3C (FAM3 metabolism regulating signaling molecule C)

2007-10-01  

Identity

HGNC
LOCATION
7q31.31
LOCUSID
ALIAS
GS3786,ILEI
FUSION GENES

Other Information

Locus ID:

NCBI: 10447
MIM: 608618
HGNC: 18664
Ensembl: ENSG00000196937

Variants:

dbSNP: 10447
ClinVar: 10447
TCGA: ENSG00000196937
COSMIC: FAM3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196937ENST00000359943Q92520
ENSG00000196937ENST00000412653C9JMN4
ENSG00000196937ENST00000426156C9JP35

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381174892024FAM3C in Cancer-Associated Adipocytes Promotes Breast Cancer Cell Survival and Metastasis.0
381174892024FAM3C in Cancer-Associated Adipocytes Promotes Breast Cancer Cell Survival and Metastasis.0
366322302023FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites.5
366322302023FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites.5
323160262021Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children.1
334922902021Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.1
335969712021The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness.10
337290942021DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway.8
343780272021Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain.11
323160262021Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children.1
334922902021Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.1
335969712021The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness.10
337290942021DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway.8
343780272021Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain.11
318800392020miR-574-3p inhibits proliferation and invasion in esophageal cancer by targeting FAM3C and MAPK1.3

Citation

Dessen P

FAM3C (FAM3 metabolism regulating signaling molecule C)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49752/fam3c