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FAM49B (family with sequence similarity 49 member B)

Identity

Alias_namesfamily with sequence similarity 49, member B
Alias_symbol (synonym)BM-009
Other aliasL1
HGNC (Hugo) FAM49B
LocusID (NCBI) 51571
Atlas_Id 57975
Location 8q24.21  [Link to chromosome band 8q24]
Location_base_pair Starts at 129839593 and ends at 129939872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYLD (16q12.1) / FAM49B (8q24.21)FAM49B (8q24.21) / AK5 (1p31.1)FAM49B (8q24.21) / ASAP1 (8q24.21)
FAM49B (8q24.21) / FAM49B (8q24.21)FAM49B (8q24.21) / KAT6A (8p11.21)FAM49B (8q24.21) / PREX2 (8q13.2)
SPIDR (8q11.21) / FAM49B (8q24.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]

Solid Tumors TT_t0108p31q24ID104516 TT_t0808p11q24ID108036 TT_t0808q13q24ID108119 TT_t0808q24q24ID108214 TT_t0816q24q12ID107907


External links

Nomenclature
HGNC (Hugo)FAM49B   25216
Cards
Entrez_Gene (NCBI)FAM49B  51571  family with sequence similarity 49 member B
AliasesBM-009; L1
GeneCards (Weizmann)FAM49B
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr8:129839593-129939872 [Contig_View]  FAM49B [Vega]
TCGA cBioPortalFAM49B
AceView (NCBI)FAM49B
Genatlas (Paris)FAM49B
WikiGenes51571
SOURCE (Princeton)FAM49B
Genetics Home Reference (NIH)FAM49B
Genomic and cartography
GoldenPath hg38 (UCSC)FAM49B  -     chr8:129839593-129939872 -  8q24.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAM49B  -     8q24.21   [Description]    (hg19-Feb_2009)
GoldenPathFAM49B - 8q24.21 [CytoView hg19]  FAM49B - 8q24.21 [CytoView hg38]
Mapping of homologs : NCBIFAM49B [Mapview hg19]  FAM49B [Mapview hg38]
OMIM617978   
Gene and transcription
Genbank (Entrez)AA975908 AF208851 AK001226 AK002059 AK130372
RefSeq transcript (Entrez)NM_001256763 NM_001330612 NM_001353242 NM_001353243 NM_001353244 NM_001353245 NM_001353246 NM_001353247 NM_001353248 NM_001353249 NM_001353250 NM_001353251 NM_001353252 NM_001353253 NM_001353254 NM_001353255 NM_001353256 NM_001353257 NM_001353258 NM_001353259 NM_001353260 NM_001353261 NM_001353262 NM_001353263 NM_001353264 NM_001353265 NM_001353266 NM_001353267 NM_001353268 NM_001353269 NM_001353270 NM_001353271 NM_001353272 NM_001353273 NM_001353274 NM_001353275 NM_001353276 NM_001353277 NM_001353278 NM_001353279 NM_001353280 NM_001353281 NM_001353282 NM_001353283 NM_001353284 NM_001353285 NM_001353286 NM_001353287 NM_001353288 NM_001353289 NM_001353290 NM_001353291 NM_001353292 NM_001353293 NM_001353294 NM_001353295 NM_001353296 NM_001353297 NM_001353298 NM_001353299 NM_001353300 NM_001353301 NM_001353302 NM_001353303 NM_001353304 NM_001353305 NM_001353306 NM_001353307 NM_001353308 NM_001353309 NM_001353310 NM_001353311 NM_001353312 NM_001353313 NM_001353314 NM_001353315 NM_001353316 NM_016623
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAM49B
Cluster EST : UnigeneHs.126941 [ NCBI ]
CGAP (NCI)Hs.126941
Gene ExpressionFAM49B [ NCBI-GEO ]   FAM49B [ EBI - ARRAY_EXPRESS ]   FAM49B [ SEEK ]   FAM49B [ MEM ]
Gene Expression Viewer (FireBrowse)FAM49B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51571
GTEX Portal (Tissue expression)FAM49B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NUQ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NUQ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NUQ9
Splice isoforms : SwissVarQ9NUQ9
PhosPhoSitePlusQ9NUQ9
Domains : Interpro (EBI)DUF1394   
Domain families : Pfam (Sanger)DUF1394 (PF07159)   
Domain families : Pfam (NCBI)pfam07159   
Conserved Domain (NCBI)FAM49B
DMDM Disease mutations51571
Blocks (Seattle)FAM49B
SuperfamilyQ9NUQ9
Peptide AtlasQ9NUQ9
IPIIPI00303318   IPI00651701   IPI00984351   IPI00979619   IPI00979101   IPI00980306   IPI00976007   IPI00979649   IPI00983688   IPI00976653   IPI01011690   IPI00982499   IPI00977851   
Protein Interaction databases
DIP (DOE-UCLA)Q9NUQ9
IntAct (EBI)Q9NUQ9
BioGRIDFAM49B
STRING (EMBL)FAM49B
ZODIACFAM49B
Ontologies - Pathways
QuickGOQ9NUQ9
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  platelet degranulation  protein binding  extracellular region  cilium  membrane  MHC class Ib protein binding, via antigen binding groove  platelet alpha granule lumen  positive regulation of interferon-gamma production  positive regulation of T cell activation  extracellular exosome  positive regulation of memory T cell activation  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  platelet degranulation  protein binding  extracellular region  cilium  membrane  MHC class Ib protein binding, via antigen binding groove  platelet alpha granule lumen  positive regulation of interferon-gamma production  positive regulation of T cell activation  extracellular exosome  positive regulation of memory T cell activation  
NDEx NetworkFAM49B
Atlas of Cancer Signalling NetworkFAM49B
Wikipedia pathwaysFAM49B
Orthology - Evolution
OrthoDB51571
Phylogenetic Trees/Animal Genes : TreeFamFAM49B
HOGENOMQ9NUQ9
Homologs : HomoloGeneFAM49B
Homology/Alignments : Family Browser (UCSC)FAM49B
Gene fusions - Rearrangements
Fusion : QuiverFAM49B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAM49B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAM49B
dbVarFAM49B
ClinVarFAM49B
1000_GenomesFAM49B 
Exome Variant ServerFAM49B
Varsome BrowserFAM49B
Genetic variants : HAPMAP51571
Genomic Variants (DGV)FAM49B [DGVbeta]
DECIPHERFAM49B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAM49B 
Mutations
ICGC Data PortalFAM49B 
TCGA Data PortalFAM49B 
Broad Tumor PortalFAM49B
OASIS PortalFAM49B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAM49B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFAM49B
Mutations and Diseases : HGMDFAM49B
BioMutasearch FAM49B
DgiDB (Drug Gene Interaction Database)FAM49B
DoCM (Curated mutations)FAM49B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAM49B (select a term)
intoGenFAM49B
Cancer3DFAM49B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617978   
Orphanet
DisGeNETFAM49B
MedgenFAM49B
Genetic Testing Registry FAM49B
NextProtQ9NUQ9 [Medical]
TSGene51571
GENETestsFAM49B
Target ValidationFAM49B
Huge Navigator FAM49B [HugePedia]
snp3D : Map Gene to Disease51571
BioCentury BCIQFAM49B
ClinGenFAM49B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51571
Chemical/Pharm GKB GenePA134990565
Clinical trialFAM49B
Miscellaneous
canSAR (ICR)FAM49B (select the gene name)
DataMed IndexFAM49B
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAM49B
EVEXFAM49B
GoPubMedFAM49B
iHOPFAM49B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:08:00 CEST 2019

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