FANCM (FA complementation group M)

2005-11-01  

Identity

HGNC
LOCATION
14q21.2
LOCUSID
ALIAS
FAAP250,KIAA1596,POF15,SPGF28

Other Information

Locus ID:

NCBI: 57697
MIM: 609644
HGNC: 23168
Ensembl: ENSG00000187790

Variants:

dbSNP: 57697
ClinVar: 57697
TCGA: ENSG00000187790
COSMIC: FANCM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187790ENST00000267430Q8IYD8
ENSG00000187790ENST00000542564Q8IYD8
ENSG00000187790ENST00000554809H0YJ14
ENSG00000187790ENST00000555484H0YJ45
ENSG00000187790ENST00000556036Q8IYD8
ENSG00000187790ENST00000556250H0YJS3
ENSG00000187790ENST00000557110H0YJN7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
FA core complexKEGGhsa_M00413
FA core complexKEGGM00413
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
182069762008The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks.134
203474282010A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.109
200644612009FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.107
203474292010MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.102
181743762008Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.99
189958302008FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
242070542013The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.75
194237272009Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.68
252887232014Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.66

Citation

Dessen P

FANCM (FA complementation group M)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43053/fancm